Detailed information of TA system TA048822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3959184..3959847
• Replicon: chromosome
• Accession: NZ_CP009364
• Organism: Yersinia frederiksenii Y225

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A0T9UMV8
• Locus tag: AW19_RS18345
• Protein ID: WP_004705513.1
• Coordinates: 3959503..3959847 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: AW19_RS18340
• Protein ID: WP_004705512.1
• Coordinates: 3959184..3959501 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AW19_RS18315	3954586..3954996	+	411	WP_042562554.1	TIGR03751 family conjugal transfer lipoprotein	-
AW19_RS18320	3954996..3957794	+	2799	WP_080868721.1	conjugative transfer ATPase	-
AW19_RS18325	3957972..3958304	-	333	WP_042562555.1	hypothetical protein	-
AW19_RS18335	3958706..3959059	+	354	WP_042562557.1	helix-turn-helix domain-containing protein	-
AW19_RS18340	3959184..3959501	-	318	WP_004705512.1	helix-turn-helix domain-containing protein	Antitoxin
AW19_RS18345	3959503..3959847	-	345	WP_004705513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AW19_RS18350	3960207..3960389	-	183	WP_042562558.1	hypothetical protein	-
AW19_RS18355	3960625..3961269	-	645	WP_042562559.1	hypothetical protein	-
AW19_RS18360	3961292..3961540	-	249	WP_042562560.1	hypothetical protein	-
AW19_RS18365	3962314..3963552	+	1239	Protein_3505	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3926414..3998242	71828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12448.25 Da
• Isoelectric Point: 9.7663

>T48822 WP_004705513.1 NZ_CP009364:c3959847-3959503 [Yersinia frederiksenii Y225]
MKPLYWVGSSKKDLQSLPEDVQDIFGYGLHLAQMGSKHSQAKPLKGFGGAGVLEVVEDYIGDTYRAVYTVKFGHAVYVLH
AFQKKSSSGIATPKPDVDKIRERLKAAESHAKGA

Nucleotide

• Length: 345 bp

>T48822 NZ_CP009364:c3959847-3959503 [Yersinia frederiksenii Y225]
ATGAAGCCACTTTATTGGGTCGGTAGCAGTAAGAAGGATCTCCAATCTCTACCTGAAGATGTACAAGATATTTTCGGCTA
CGGCCTGCATTTGGCACAGATGGGCAGTAAACATTCCCAAGCTAAGCCATTGAAAGGGTTTGGTGGTGCGGGTGTACTGG
AAGTTGTTGAGGATTATATCGGTGATACCTACCGAGCGGTTTACACTGTTAAATTTGGTCATGCGGTGTATGTGTTACAT
GCATTCCAGAAAAAATCTTCATCAGGAATAGCCACGCCAAAGCCAGATGTGGATAAGATCCGCGAGCGGCTGAAAGCCGC
AGAAAGTCATGCTAAAGGAGCATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11529.44 Da
• Isoelectric Point: 10.6107

>AT48822 WP_004705512.1 NZ_CP009364:c3959501-3959184 [Yersinia frederiksenii Y225]
MSHDIEISSGNVYADLGKDNAEEMQVKAQLATTIGNIIKSRRLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKARRTPGSLKVVFA

Nucleotide

• Length: 318 bp

>AT48822 NZ_CP009364:c3959501-3959184 [Yersinia frederiksenii Y225]
ATGAGCCATGATATCGAAATCAGCAGCGGTAACGTTTATGCCGATCTTGGCAAAGATAATGCTGAAGAAATGCAGGTAAA
AGCACAGCTTGCTACCACTATTGGTAACATTATTAAAAGCCGCCGCCTGACACAAGAACAGGCCGCCAAGCTGCTGGGGA
TGACTCAGCCTAAGCTGTCTAATATGTTGCGCGGGCAATTTCGAGGCATTAGCGAGGCCAAAATGTTGGAATGCCTGACC
CGTTTGGGGCGAGATGTGCAAATTGTCGTCGGGAAAGCGCGCCGCACTCCTGGTAGCCTGAAAGTGGTGTTCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0T9UMV8