Detailed information of TA system TA048821

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 2662018..2662721
• Replicon: chromosome
• Accession: NZ_CP009364
• Organism: Yersinia frederiksenii Y225

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AW19_RS12510
• Protein ID: WP_038630821.1
• Coordinates: 2662018..2662383 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: AW19_RS12515
• Protein ID: WP_038630819.1
• Coordinates: 2662389..2662721 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AW19_RS12480	2658389..2658889	-	501	WP_038630827.1	type VI secretion system contractile sheath small subunit	-
AW19_RS12485	2659899..2660129	+	231	WP_038639291.1	PerC family transcriptional regulator	-
AW19_RS12490	2660211..2660354	+	144	Protein_2369	homocysteine S-methyltransferase	-
AW19_RS12495	2660699..2661130	+	432	WP_038630823.1	antirestriction protein	-
AW19_RS12500	2661163..2661636	+	474	WP_038639288.1	DNA repair protein RadC	-
AW19_RS12505	2661630..2661962	+	333	WP_051957643.1	hypothetical protein	-
AW19_RS12510	2662018..2662383	+	366	WP_038630821.1	TA system toxin CbtA family protein	Toxin
AW19_RS12515	2662389..2662721	+	333	WP_038630819.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AW19_RS12520	2662808..2663674	+	867	WP_038630817.1	DUF4942 domain-containing protein	-
AW19_RS12525	2663874..2664197	+	324	WP_038630815.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AW19_RS12530	2664184..2664471	+	288	WP_012104592.1	helix-turn-helix transcriptional regulator	-
AW19_RS12535	2664872..2665171	+	300	Protein_2378	DUF4102 domain-containing protein	-
AW19_RS12540	2665287..2666651	-	1365	WP_042562471.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (11-101)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13396.31 Da
• Isoelectric Point: 6.8773

>T48821 WP_038630821.1 NZ_CP009364:2662018-2662383 [Yersinia frederiksenii Y225]
MKPNPTTAGALPAPAIYQQLLAFLLEHHYGLSLNDTPYHDEQMITQQIEQGISVGDTINTLVEKYALVRIGRTGFSALAQ
DPMLSKGDIVRARQAAGLWRAHFPPTLLYSTESLNPIQPQR

Nucleotide

• Length: 366 bp

>T48821 NZ_CP009364:2662018-2662383 [Yersinia frederiksenii Y225]
ATGAAACCAAACCCCACAACAGCGGGTGCATTACCCGCGCCTGCTATTTATCAACAACTACTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGATGATTACGCAACAGATTGAACAAGGGATTTCAG
TCGGCGACACCATCAACACACTGGTTGAGAAATATGCCTTAGTGCGTATTGGTCGTACCGGGTTCAGTGCATTGGCACAA
GACCCGATGTTGAGCAAAGGTGATATCGTGCGGGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACTCAACCGAGTCCCTCAATCCTATTCAACCACAGAGATAG

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12155.83 Da
• Isoelectric Point: 7.0602

>AT48821 WP_038630819.1 NZ_CP009364:2662389-2662721 [Yersinia frederiksenii Y225]
MDNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPTLITKLESQLLSGALDPRRQQG
ITVRHGEFVCEADTLGSHGYLYIAVYQKLA

Nucleotide

• Length: 333 bp

>AT48821 NZ_CP009364:2662389-2662721 [Yersinia frederiksenii Y225]
ATGGATAACCACATTACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCACACTGATAACCAAACTGGAATCGCAGTTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACCGTTCGGCATGGGGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTACCTCTATATCGCTGTGTATCA
GAAACTGGCTTGA