Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2238679..2239297 Replicon chromosome
Accession NZ_CP009364
Organism Yersinia frederiksenii Y225

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag AW19_RS10565 Protein ID WP_002208622.1
Coordinates 2239094..2239297 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A386HG68
Locus tag AW19_RS10560 Protein ID WP_038631539.1
Coordinates 2238679..2239047 (+) Length 123 a.a.

Genomic Context

AW19_RS10530AW19_RS10535AW19_RS10555AW19_RS10560AW19_RS10565AW19_RS10570AW19_RS10580AW19_RS10540AW19_RS10545AW19_RS10550AW19_RS10575AW19_RS10585AW19_RS10590
Location: 2234352..2234612 (261 bp)
Type: Others
Protein ID: WP_038631547.1
Location: 2234628..2234771 (144 bp)
Type: Others
Protein ID: WP_038631546.1
Location: 2238167..2238520 (354 bp)
Type: Others
Protein ID: WP_038631541.1
Location: 2238679..2239047 (369 bp)
Type: Antitoxin
Protein ID: WP_038631539.1
Location: 2239094..2239297 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 2240254..2240565 (312 bp)
Type: Others
Protein ID: WP_186368485.1
Location: 2241391..2242251 (861 bp)
Type: Others
Protein ID: WP_038631531.1
Location: 2234893..2235771 (879 bp)
Type: Others
Protein ID: WP_038631545.1
Location: 2235818..2236675 (858 bp)
Type: Others
Protein ID: WP_038631544.1
Location: 2236672..2237400 (729 bp)
Type: Others
Protein ID: WP_038631543.1
Location: 2240609..2241133 (525 bp)
Type: Others
Protein ID: WP_038631533.1
Location: 2242333..2243622 (1290 bp)
Type: Others
Protein ID: WP_038639390.1
Location: 2243662..2244000 (339 bp)
Type: Others
Protein ID: WP_002208627.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AW19_RS105302234352..2234612+261WP_038631547.1type B 50S ribosomal protein L31-
AW19_RS105352234628..2234771+144WP_038631546.1type B 50S ribosomal protein L36-
AW19_RS105402234893..2235771-879WP_038631545.1metal ABC transporter substrate-binding protein-
AW19_RS105452235818..2236675-858WP_038631544.1metal ABC transporter permease-
AW19_RS105502236672..2237400-729WP_038631543.1ABC transporter ATP-binding protein-
AW19_RS105552238167..2238520+354WP_038631541.1hypothetical protein-
AW19_RS105602238679..2239047+369WP_038631539.1Hha toxicity modulator TomBAntitoxin
AW19_RS105652239094..2239297+204WP_002208622.1expression modulating protein YmoAToxin
AW19_RS105702240254..2240565+312WP_186368485.1MGMT family protein-
AW19_RS105752240609..2241133-525WP_038631533.1YbaY family lipoprotein-
AW19_RS105802241391..2242251+861WP_038631531.1acyl-CoA thioesterase II-
AW19_RS105852242333..2243622-1290WP_038639390.1ammonium transporter AmtB-
AW19_RS105902243662..2244000-339WP_002208627.1P-II family nitrogen regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T48819 WP_002208622.1 NZ_CP009364:2239094-2239297 [Yersinia frederiksenii Y225]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T48819 NZ_CP009364:2239094-2239297 [Yersinia frederiksenii Y225]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACAACTATTGATACATTAGAACGTGTAATTGAAAAGAATAA
GTACGAACTTTCAGATGATGAGCTGGAATTATTTTATTCAGCTGCAGACCATCGCTTAGCTGAGCTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTGTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14190.97 Da        Isoelectric Point: 4.5140

>AT48819 WP_038631539.1 NZ_CP009364:2238679-2239047 [Yersinia frederiksenii Y225]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGADLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT48819 NZ_CP009364:2238679-2239047 [Yersinia frederiksenii Y225]
ATGGATGAGTACTCACCGAAGCGGCATGACATTGCCCAATTGAAGTTTTTATGTGAGAGTTTGTATGATGAAGGCATTGC
CACCCTTGGTGACAGCCACCATGGTTGGGTAAATGACCCGACTTCTGCCGTAAATCTACAATTGAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCTGATGGCGCAGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTATGGGATCAATGACCCTGAATTGCGTCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2K5S

Antitoxin

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Source
ID
Structure
No matching records found

References