Detailed information of TA system TA048810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1589229..1589742
• Replicon: chromosome
• Accession: NZ_CP009364
• Organism: Yersinia frederiksenii Y225

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A386HFI9
• Locus tag: AW19_RS07650
• Protein ID: WP_038632447.1
• Coordinates: 1589458..1589742 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: AW19_RS07645
• Protein ID: WP_012105237.1
• Coordinates: 1589229..1589468 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AW19_RS07630	1585017..1586225	+	1209	WP_038632455.1	sodium/glutamate symporter	-
AW19_RS07635	1586345..1587217	-	873	WP_038632453.1	23S rRNA pseudouridine(2604) synthase RluF	-
AW19_RS07640	1587486..1588649	+	1164	WP_071841717.1	class C beta-lactamase	-
AW19_RS21595	1588932..1589102	-	171	WP_187142909.1	hypothetical protein	-
AW19_RS07645	1589229..1589468	+	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AW19_RS07650	1589458..1589742	+	285	WP_038632447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AW19_RS07655	1589753..1590380	-	628	Protein_1422	terminase small subunit	-
AW19_RS07660	1590906..1591247	-	342	WP_038632445.1	YebY family protein	-
AW19_RS07665	1591344..1592228	-	885	WP_038632443.1	copper homeostasis membrane protein CopD	-
AW19_RS07670	1592230..1592616	-	387	WP_038632441.1	CopC domain-containing protein YobA	-
AW19_RS07675	1593006..1593515	-	510	WP_038632439.1	non-heme ferritin	-
AW19_RS07680	1593909..1594142	+	234	WP_038632437.1	DNA polymerase III subunit theta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1587468..1596326	8858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11172.92 Da
• Isoelectric Point: 10.1967

>T48810 WP_038632447.1 NZ_CP009364:1589458-1589742 [Yersinia frederiksenii Y225]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREEAYSEAGNRV

Nucleotide

• Length: 285 bp

>T48810 NZ_CP009364:1589458-1589742 [Yersinia frederiksenii Y225]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTAAAGGAATGGCATAAGCTCGGCGATACCGTACGCCAGCAATTTAA
GAAAAAGTTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGTTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAATCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT48810 WP_012105237.1 NZ_CP009364:1589229-1589468 [Yersinia frederiksenii Y225]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT48810 NZ_CP009364:1589229-1589468 [Yersinia frederiksenii Y225]
ATGGGTAACATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAGCTGGGGGTCACCCC
CTCTGATTTGCTGCGCCAGACACTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA