Detailed information of TA system TA048809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1424945..1425935
• Replicon: chromosome
• Accession: NZ_CP009364
• Organism: Yersinia frederiksenii Y225

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A386HEZ3
• Locus tag: AW19_RS06870
• Protein ID: WP_038632724.1
• Coordinates: 1425477..1425935 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A386HEX0
• Locus tag: AW19_RS06865
• Protein ID: WP_038632726.1
• Coordinates: 1424945..1425391 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AW19_RS06845	1420557..1421264	+	708	WP_038632734.1	murein tripeptide amidase MpaA	-
AW19_RS06850	1421261..1422232	-	972	WP_038632732.1	L-Ala-D/L-Glu epimerase	-
AW19_RS06855	1422384..1422887	+	504	WP_038632730.1	thiol peroxidase	-
AW19_RS06860	1423048..1424625	-	1578	WP_038632728.1	transcriptional regulator TyrR	-
AW19_RS06865	1424945..1425391	+	447	WP_038632726.1	DUF2384 domain-containing protein	Antitoxin
AW19_RS06870	1425477..1425935	+	459	WP_038632724.1	RES family NAD+ phosphorylase	Toxin
AW19_RS06875	1425942..1427003	-	1062	WP_038632723.1	YcjF family protein	-
AW19_RS06880	1427000..1428397	-	1398	WP_038632717.1	YcjX family protein	-
AW19_RS06885	1428378..1428617	-	240	WP_038632715.1	phage shock protein PspD	-
AW19_RS06890	1428663..1429013	-	351	WP_038639499.1	envelope stress response membrane protein PspC	-
AW19_RS06895	1429067..1429294	-	228	WP_038632713.1	envelope stress response membrane protein PspB	-
AW19_RS06900	1429399..1430064	-	666	WP_038632711.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-148)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17292.75 Da
• Isoelectric Point: 5.1666

>T48809 WP_038632724.1 NZ_CP009364:1425477-1425935 [Yersinia frederiksenii Y225]
MKFYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSHILLLQPQ
DWPADWRSDPAPATTMDIGTEWLELESSLALLVPSTLVPSENNLLLNPRHKDFQACLNSVKPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T48809 NZ_CP009364:1425477-1425935 [Yersinia frederiksenii Y225]
ATGAAGTTCTACCGTATTGTGATGCGCCGTTATCTGGCGTCAACCTGGACCGGTTATGGCGCCGAAATCTATGGTGGCCG
TTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTGTCTTTGGCGATGCTGGAAACATTGGTACATATCC
AAGATAGCTCAACGCTGAGCGAGTTCGAGCTATTCCAGATTGAAATCGAAGATAGCCATATTCTGTTACTTCAACCGCAA
GATTGGCCTGCTGACTGGCGCAGTGATCCCGCACCGGCGACCACAATGGATATCGGCACCGAATGGTTAGAGCTGGAATC
ATCACTTGCATTACTGGTTCCATCCACTCTGGTGCCGTCAGAAAACAATCTACTGCTCAACCCTCGGCATAAAGATTTTC
AAGCTTGCTTAAACAGTGTTAAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16177.61 Da
• Isoelectric Point: 9.1260

>AT48809 WP_038632726.1 NZ_CP009364:1424945-1425391 [Yersinia frederiksenii Y225]
MRAYHPTPATKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDGIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIAWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT48809 NZ_CP009364:1424945-1425391 [Yersinia frederiksenii Y225]
ATGAGAGCATATCACCCGACCCCAGCGACCAAAACTGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGCAC
TGTATTGGTCGATAGTATCAAAATGGGTTTTTCAGTTGATGTCATCGACGGTATCCATTTATGGGCTTCTATCCCTAAAG
CTGAAATATTGCGGGCCACGGGTATTCCCAGCCGCAGTCTGACCCGCAGACGCACACATGATGGCCGTTTCACCCCTGAA
GAGAGTGAGCGAATTGCCCGTTTCGTCCGGGTAATGGATGCCGCAGTTGATCTATTTGGCGGTGATAAGGGCAAAGCTAT
CGCCTGGATGTCTACCCCGATTAAAGGTCTTGGTCACCGCAGCCCCGACTCCTTGCTGGAAACGGAAACCGGTGCACTGG
AAGTCTGTGATTTAATTGGGCGTTTGGAGCACGGTGTATTTTCATAA