Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 13346..13923 Replicon plasmid unnsmrf
Accession NZ_CP009363
Organism Yersinia frederiksenii Y225

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AW19_RS00090 Protein ID WP_042562281.1
Coordinates 13621..13923 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AW19_RS00085 Protein ID WP_042562280.1
Coordinates 13346..13624 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AW19_RS00065 10520..11035 + 516 WP_042562276.1 J domain-containing protein -
AW19_RS00070 11088..11633 + 546 WP_042562277.1 hypothetical protein -
AW19_RS00075 11692..11982 + 291 WP_042562278.1 hypothetical protein -
AW19_RS00080 11998..12201 + 204 WP_042562279.1 helix-turn-helix domain-containing protein -
AW19_RS00085 13346..13624 - 279 WP_042562280.1 putative addiction module antidote protein Antitoxin
AW19_RS00090 13621..13923 - 303 WP_042562281.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AW19_RS00095 14175..14621 + 447 WP_042562282.1 hypothetical protein -
AW19_RS00100 14949..15683 - 735 WP_042562283.1 hypothetical protein -
AW19_RS00105 15739..16452 - 714 WP_042562284.1 hypothetical protein -
AW19_RS00110 16449..17102 - 654 WP_042562285.1 hypothetical protein -
AW19_RS00115 17412..17759 + 348 WP_042562286.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..55362 55362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-87)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11228.00 Da        Isoelectric Point: 9.8105

>T48807 WP_042562281.1 NZ_CP009363:c13923-13621 [Yersinia frederiksenii Y225]
MITVLSTETFDTWIDALKDIRAKTKIQARIRRLKNGNFGDIEPVGEGFSEMRIHEGKGYRVYLKSHGSIIVVLLCGGDKS
TQQKDITKAKAIYKSIEGEL

Download         Length: 303 bp

>T48807 NZ_CP009363:c13923-13621 [Yersinia frederiksenii Y225]
ATGATAACTGTATTAAGTACGGAAACATTTGATACTTGGATTGATGCCCTAAAAGACATTAGGGCTAAGACAAAAATTCA
GGCACGTATTCGCAGACTGAAAAACGGAAATTTTGGCGATATAGAGCCAGTAGGTGAAGGGTTTTCAGAAATGCGTATTC
ATGAAGGGAAAGGGTACAGGGTTTATCTGAAAAGCCACGGAAGTATTATCGTTGTTTTGCTTTGTGGGGGCGATAAAAGC
ACACAGCAAAAAGATATCACCAAAGCTAAGGCAATCTATAAATCAATCGAGGGGGAGCTATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10157.72 Da        Isoelectric Point: 5.6105

>AT48807 WP_042562280.1 NZ_CP009363:c13624-13346 [Yersinia frederiksenii Y225]
MKLKEYDIAEHLNSEEEMQMYLNEILEDGDPALVLSALGDIARAKNMSQLSREVGMSREGLYHALSGKGNPTFSAMMKIT
KALGLKLHFTGA

Download         Length: 279 bp

>AT48807 NZ_CP009363:c13624-13346 [Yersinia frederiksenii Y225]
ATGAAGCTGAAAGAATACGATATTGCAGAGCACTTAAATAGTGAAGAAGAAATGCAAATGTACCTTAACGAAATTTTGGA
AGATGGAGATCCAGCGTTGGTACTCTCTGCACTTGGGGATATAGCCAGAGCAAAAAATATGAGCCAGCTTTCGAGAGAGG
TTGGTATGTCAAGAGAGGGGCTATATCACGCCCTTTCAGGGAAAGGAAATCCAACATTCAGCGCTATGATGAAAATAACG
AAAGCTCTAGGGCTTAAACTTCATTTCACAGGTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References