Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2123930..2124444 Replicon chromosome
Accession NZ_CP009361
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag KQ76_RS10630 Protein ID WP_000581791.1
Coordinates 2123930..2124139 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KQ76_RS10635 Protein ID WP_000138934.1
Coordinates 2124151..2124444 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ76_RS10610 2119819..2120889 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
KQ76_RS10615 2121207..2122409 + 1203 WP_001109939.1 rod shape-determining protein RodA -
KQ76_RS14980 2122570..2123253 - 684 Protein_2011 transposase -
KQ76_RS10625 2123665..2123802 - 138 WP_000828354.1 hypothetical protein -
KQ76_RS10630 2123930..2124139 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
KQ76_RS10635 2124151..2124444 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KQ76_RS10640 2124610..2126094 + 1485 WP_000571560.1 cardiolipin synthase -
KQ76_RS10645 2126122..2126769 + 648 WP_001187612.1 HD domain-containing protein -
KQ76_RS10655 2127382..2128254 - 873 WP_000725802.1 membrane protein insertase YidC -
KQ76_RS10660 2128340..2128981 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T48800 WP_000581791.1 NZ_CP009361:c2124139-2123930 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T48800 NZ_CP009361:c2124139-2123930 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT48800 WP_000138934.1 NZ_CP009361:c2124444-2124151 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT48800 NZ_CP009361:c2124444-2124151 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References