Detailed information of TA system TA048798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2050486..2051015
• Replicon: chromosome
• Accession: NZ_CP009361
• Organism: Staphylococcus aureus strain ATCC 25923

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0C6DV13
• Locus tag: KQ76_RS10260
• Protein ID: WP_001103929.1
• Coordinates: 2050486..2050803 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: KQ76_RS10265
• Protein ID: WP_001058486.1
• Coordinates: 2050806..2051015 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ76_RS10230	2045796..2046137	-	342	WP_001161492.1	hypothetical protein	-
KQ76_RS10235	2046484..2047125	-	642	WP_038413070.1	pathogenicity island protein	-
KQ76_RS10240	2047122..2047406	-	285	WP_000998182.1	hypothetical protein	-
KQ76_RS10245	2047408..2047770	-	363	WP_001039171.1	hypothetical protein	-
KQ76_RS10250	2048067..2049536	-	1470	WP_001834090.1	virulence-associated E family protein	-
KQ76_RS10255	2049553..2050422	-	870	WP_001002839.1	primase alpha helix C-terminal domain-containing protein	-
KQ76_RS10260	2050486..2050803	-	318	WP_001103929.1	DUF1474 family protein	Toxin
KQ76_RS10265	2050806..2051015	-	210	WP_001058486.1	hypothetical protein	Antitoxin
KQ76_RS15120	2051008..2051154	-	147	WP_000833313.1	hypothetical protein	-
KQ76_RS10270	2051151..2051468	-	318	WP_000481972.1	helix-turn-helix domain-containing protein	-
KQ76_RS10275	2051482..2052123	-	642	WP_000595329.1	phage repressor protein	-
KQ76_RS10280	2052127..2052339	-	213	WP_000448765.1	helix-turn-helix transcriptional regulator	-
KQ76_RS10285	2052493..2053155	+	663	WP_001070979.1	helix-turn-helix transcriptional regulator	-
KQ76_RS10290	2053168..2054340	+	1173	WP_000024832.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2038084..2056385	18301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12666.19 Da
• Isoelectric Point: 4.5462

>T48798 WP_001103929.1 NZ_CP009361:c2050803-2050486 [Staphylococcus aureus]
MNWEIKDLICDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HELEKASSENFDEESDDAQKLKITE

Nucleotide

• Length: 318 bp

>T48798 NZ_CP009361:c2050803-2050486 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATATGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAATTAGAAAAAGCATCATCTGAGAACTTTGACGAGGAATCAGATGACGCGCAGAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT48798 WP_001058486.1 NZ_CP009361:c2051015-2050806 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT48798 NZ_CP009361:c2051015-2050806 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A0C6DV13