Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3858040..3858683 Replicon chromosome
Accession NZ_CP009360
Organism Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KV38_RS17895 Protein ID WP_033718005.1
Coordinates 3858258..3858683 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KV38_RS17890 Protein ID WP_033718008.1
Coordinates 3858040..3858261 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KV38_RS17865 3853662..3854204 + 543 WP_071321477.1 cupin domain-containing protein -
KV38_RS17870 3854401..3854919 + 519 WP_071321478.1 MarR family transcriptional regulator -
KV38_RS17875 3855216..3855992 + 777 WP_033718003.1 SDR family oxidoreductase -
KV38_RS17880 3856099..3856755 + 657 WP_033718004.1 isochorismatase family protein -
KV38_RS17885 3856859..3857302 + 444 WP_071321479.1 nitroreductase family deazaflavin-dependent oxidoreductase -
KV38_RS17890 3858040..3858261 + 222 WP_033718008.1 hypothetical protein Antitoxin
KV38_RS17895 3858258..3858683 + 426 WP_033718005.1 PIN domain nuclease Toxin
KV38_RS17900 3858774..3858965 + 192 WP_075545912.1 hypothetical protein -
KV38_RS17905 3859652..3860410 - 759 Protein_3536 alpha/beta hydrolase -
KV38_RS17910 3860749..3861111 + 363 WP_050594515.1 metalloregulator ArsR/SmtB family transcription factor -
KV38_RS17915 3861108..3861557 + 450 Protein_3538 SRPBCC family protein -
KV38_RS17920 3861618..3861929 + 312 WP_080691733.1 hypothetical protein -
KV38_RS17925 3861921..3862421 - 501 WP_158006314.1 IS30 family transposase -
KV38_RS17930 3862469..3862870 - 402 WP_080691732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15580.73 Da        Isoelectric Point: 6.3329

>T48790 WP_033718005.1 NZ_CP009360:3858258-3858683 [Mycobacterium avium subsp. hominissuis]
MTEASWLIDKSALARLAHSHEPEIWSNRIERGLVHISNLTRLEIGYSAQSGDVARREFRESPLAAMPVEYLTPKIEDRAL
QVQLLLADRGQHRGPSIPDLVIAATAELARLTVLHVDKDFDTIAAITGQPVTRLAFTSSST

Download         Length: 426 bp

>T48790 NZ_CP009360:3858258-3858683 [Mycobacterium avium subsp. hominissuis]
ATGACGGAAGCGTCATGGCTGATCGACAAATCGGCCCTGGCGCGCCTCGCGCACAGCCACGAGCCGGAAATCTGGAGCAA
TCGAATCGAGCGCGGACTAGTCCACATCAGCAATCTGACCCGTCTAGAAATCGGGTATTCGGCTCAGTCCGGTGACGTCG
CTCGACGAGAGTTCCGCGAATCCCCCTTGGCTGCAATGCCAGTCGAGTACCTGACGCCGAAAATTGAAGACCGTGCATTG
CAAGTCCAGCTGCTGCTGGCCGATCGCGGCCAACACCGGGGGCCGTCGATCCCCGATCTCGTCATCGCGGCCACCGCCGA
GCTGGCACGATTGACCGTCCTGCACGTCGACAAAGACTTCGACACCATCGCCGCGATAACCGGACAACCCGTAACGCGGC
TTGCCTTCACCAGTAGCAGTACGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8178.22 Da        Isoelectric Point: 5.0334

>AT48790 WP_033718008.1 NZ_CP009360:3858040-3858261 [Mycobacterium avium subsp. hominissuis]
VSDVLIRDVPDDVLAGLDARAAELGLSRVEYIRRRLAQDARAPRVSVTHEDLHRMGRNLAGLAEDDLMNQAWQ

Download         Length: 222 bp

>AT48790 NZ_CP009360:3858040-3858261 [Mycobacterium avium subsp. hominissuis]
GTGAGCGACGTGCTGATCCGCGATGTTCCTGACGATGTGCTCGCTGGGCTCGATGCGCGAGCTGCCGAGTTGGGCTTATC
GCGCGTTGAGTACATTCGCCGTCGCCTTGCTCAAGACGCTCGCGCGCCACGTGTGTCGGTCACCCACGAAGACCTCCATC
GGATGGGGCGCAACCTTGCGGGCCTGGCCGAGGACGACCTGATGAACCAGGCCTGGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References