Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 1916726..1917390 Replicon chromosome
Accession NZ_CP009360
Organism Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZII2
Locus tag KV38_RS09110 Protein ID WP_023861453.1
Coordinates 1916983..1917390 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A2ZI58
Locus tag KV38_RS09105 Protein ID WP_033719712.1
Coordinates 1916726..1916986 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KV38_RS09085 1912144..1912806 + 663 WP_023861449.1 TetR/AcrR family transcriptional regulator -
KV38_RS09090 1913001..1914461 + 1461 WP_033719709.1 serine/threonine protein kinase -
KV38_RS09095 1914659..1915927 - 1269 WP_033719710.1 cytochrome P450 -
KV38_RS09100 1916093..1916545 + 453 WP_033719711.1 VOC family protein -
KV38_RS09105 1916726..1916986 + 261 WP_033719712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KV38_RS09110 1916983..1917390 + 408 WP_023861453.1 type II toxin-antitoxin system VapC family toxin Toxin
KV38_RS09115 1917537..1919101 - 1565 Protein_1789 serine/threonine protein kinase -
KV38_RS09120 1919338..1919859 + 522 WP_033719714.1 carboxymuconolactone decarboxylase family protein -
KV38_RS09125 1919856..1920401 + 546 WP_033719715.1 carboxymuconolactone decarboxylase family protein -
KV38_RS09130 1920522..1921052 + 531 WP_019734505.1 TetR/AcrR family transcriptional regulator -
KV38_RS09135 1921041..1922210 - 1170 WP_071321406.1 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14414.44 Da        Isoelectric Point: 4.5860

>T48788 WP_023861453.1 NZ_CP009360:1916983-1917390 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T48788 NZ_CP009360:1916983-1917390 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGC
GCGAATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCG
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCAGCCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTCGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9608.98 Da        Isoelectric Point: 11.7137

>AT48788 WP_033719712.1 NZ_CP009360:1916726-1916986 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT48788 NZ_CP009360:1916726-1916986 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2ZII2

Antitoxin

Source ID Structure
AlphaFold DB A0A2A2ZI58

References