Detailed information of TA system TA048787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1117699..1118263
• Replicon: chromosome
• Accession: NZ_CP009360
• Organism: Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2A2ZLT9
• Locus tag: KV38_RS05555
• Protein ID: WP_023868517.1
• Coordinates: 1117892..1118263 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KV38_RS05550
• Protein ID: WP_011724021.1
• Coordinates: 1117699..1117905 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KV38_RS05530	1112956..1113954	+	999	WP_023868514.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
KV38_RS05535	1113978..1115183	-	1206	WP_179148812.1	hypothetical protein	-
KV38_RS05540	1115314..1116387	+	1074	WP_023868516.1	redox-regulated ATPase YchF	-
KV38_RS05545	1116587..1117531	+	945	WP_003875389.1	HNH endonuclease	-
KV38_RS05550	1117699..1117905	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KV38_RS05555	1117892..1118263	+	372	WP_023868517.1	type II toxin-antitoxin system VapC family toxin	Toxin
KV38_RS05560	1118363..1118803	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
KV38_RS05565	1118869..1119606	-	738	WP_023868518.1	glucose 1-dehydrogenase	-
KV38_RS05570	1119681..1120286	+	606	WP_095956146.1	TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator	-
KV38_RS05575	1120388..1120786	+	399	WP_071321381.1	VOC family protein	-
KV38_RS05580	1120855..1121238	+	384	WP_011724026.1	hypothetical protein	-
KV38_RS05585	1121308..1121661	+	354	WP_023865350.1	hypothetical protein	-
KV38_RS05590	1121818..1122183	+	366	Protein_1096	hypothetical protein	-
KV38_RS05595	1122813..1123136	+	324	WP_044543559.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1110788..1118803	8015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13754.08 Da
• Isoelectric Point: 6.6032

>T48787 WP_023868517.1 NZ_CP009360:1117892-1118263 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T48787 NZ_CP009360:1117892-1118263 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAAAGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT48787 WP_011724021.1 NZ_CP009360:1117699-1117905 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT48787 NZ_CP009360:1117699-1117905 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A2A2ZLT9