Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1117699..1118263 Replicon chromosome
Accession NZ_CP009360
Organism Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZLT9
Locus tag KV38_RS05555 Protein ID WP_023868517.1
Coordinates 1117892..1118263 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KV38_RS05550 Protein ID WP_011724021.1
Coordinates 1117699..1117905 (+) Length 69 a.a.

Genomic Context

KV38_RS05530KV38_RS05540KV38_RS05545KV38_RS05550KV38_RS05555KV38_RS05560KV38_RS05570KV38_RS05575KV38_RS05580KV38_RS05585KV38_RS05590KV38_RS05595KV38_RS05535KV38_RS05565
Location: 1112956..1113954 (999 bp)
Type: Others
Protein ID: WP_023868514.1
Location: 1115314..1116387 (1074 bp)
Type: Others
Protein ID: WP_023868516.1
Location: 1116587..1117531 (945 bp)
Type: Others
Protein ID: WP_003875389.1
Location: 1117699..1117905 (207 bp)
Type: Antitoxin
Protein ID: WP_011724021.1
Location: 1117892..1118263 (372 bp)
Type: Toxin
Protein ID: WP_023868517.1
Location: 1118363..1118803 (441 bp)
Type: Others
Protein ID: WP_003875392.1
Location: 1119681..1120286 (606 bp)
Type: Others
Protein ID: WP_095956146.1
Location: 1120388..1120786 (399 bp)
Type: Others
Protein ID: WP_071321381.1
Location: 1120855..1121238 (384 bp)
Type: Others
Protein ID: WP_011724026.1
Location: 1121308..1121661 (354 bp)
Type: Others
Protein ID: WP_023865350.1
Location: 1121818..1122183 (366 bp)
Type: Others
Protein ID: Protein_1096
Location: 1122813..1123136 (324 bp)
Type: Others
Protein ID: WP_044543559.1
Location: 1113978..1115183 (1206 bp)
Type: Others
Protein ID: WP_179148812.1
Location: 1118869..1119606 (738 bp)
Type: Others
Protein ID: WP_023868518.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KV38_RS055301112956..1113954+999WP_023868514.14-hydroxy-3-methylbut-2-enyl diphosphate reductase-
KV38_RS055351113978..1115183-1206WP_179148812.1hypothetical protein-
KV38_RS055401115314..1116387+1074WP_023868516.1redox-regulated ATPase YchF-
KV38_RS055451116587..1117531+945WP_003875389.1HNH endonuclease-
KV38_RS055501117699..1117905+207WP_011724021.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
KV38_RS055551117892..1118263+372WP_023868517.1type II toxin-antitoxin system VapC family toxinToxin
KV38_RS055601118363..1118803+441WP_003875392.1nitroreductase family deazaflavin-dependent oxidoreductase-
KV38_RS055651118869..1119606-738WP_023868518.1glucose 1-dehydrogenase-
KV38_RS055701119681..1120286+606WP_095956146.1TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator-
KV38_RS055751120388..1120786+399WP_071321381.1VOC family protein-
KV38_RS055801120855..1121238+384WP_011724026.1hypothetical protein-
KV38_RS055851121308..1121661+354WP_023865350.1hypothetical protein-
KV38_RS055901121818..1122183+366Protein_1096hypothetical protein-
KV38_RS055951122813..1123136+324WP_044543559.1antibiotic biosynthesis monooxygenase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1110788..11188038015


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13754.08 Da        Isoelectric Point: 6.6032

>T48787 WP_023868517.1 NZ_CP009360:1117892-1118263 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Download         Length: 372 bp

>T48787 NZ_CP009360:1117892-1118263 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAAAGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7261.25 Da        Isoelectric Point: 11.0634

>AT48787 WP_011724021.1 NZ_CP009360:1117699-1117905 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Download         Length: 207 bp

>AT48787 NZ_CP009360:1117699-1117905 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2A2ZLT9

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References