Detailed information of TA system TA048786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 892983..893636
• Replicon: chromosome
• Accession: NZ_CP009360
• Organism: Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: KV38_RS04510
• Protein ID: WP_003872880.1
• Coordinates: 893175..893636 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: X7V3T8
• Locus tag: KV38_RS04505
• Protein ID: WP_019733774.1
• Coordinates: 892983..893171 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KV38_RS04495	888965..890551	+	1587	WP_033718980.1	serine hydrolase	-
KV38_RS04500	890548..892920	+	2373	WP_033713171.1	cation-translocating P-type ATPase	-
KV38_RS04505	892983..893171	+	189	WP_019733774.1	antitoxin	Antitoxin
KV38_RS04510	893175..893636	+	462	WP_003872880.1	SRPBCC family protein	Toxin
KV38_RS04515	893705..894139	+	435	WP_023900194.1	hypothetical protein	-
KV38_RS04520	895135..896718	+	1584	WP_003872878.1	DUF4185 domain-containing protein	-
KV38_RS04525	896758..897144	+	387	WP_019733869.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16626.19 Da
• Isoelectric Point: 9.5654

>T48786 WP_003872880.1 NZ_CP009360:893175-893636 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T48786 NZ_CP009360:893175-893636 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGCTCGGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCAGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGCTCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6793.46 Da
• Isoelectric Point: 4.4865

>AT48786 WP_019733774.1 NZ_CP009360:892983-893171 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKFEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Nucleotide

• Length: 189 bp

>AT48786 NZ_CP009360:892983-893171 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGTTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACTGGCGACCAGCAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: X7V3T8