Detailed information of TA system TA048784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1250585..1251123
• Replicon: chromosome
• Accession: NZ_CP009355
• Organism: Vibrio tubiashii ATCC 19109

Toxin (Protein)

• Gene name: parE
• Uniprot ID: F9TDA0
• Locus tag: IX91_RS20785
• Protein ID: WP_004748748.1
• Coordinates: 1250824..1251123 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F9TD99
• Locus tag: IX91_RS20780
• Protein ID: WP_004748747.1
• Coordinates: 1250585..1250827 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IX91_RS20760	1246375..1247025	+	651	WP_004748742.1	isoprenoid biosynthesis glyoxalase ElbB	-
IX91_RS20765	1247316..1248464	+	1149	WP_004748743.1	L-threonine dehydrogenase	-
IX91_RS20770	1248925..1249284	+	360	WP_004748745.1	hypothetical protein	-
IX91_RS20775	1249288..1250517	+	1230	WP_004748746.1	hypothetical protein	-
IX91_RS20780	1250585..1250827	+	243	WP_004748747.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
IX91_RS20785	1250824..1251123	+	300	WP_004748748.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IX91_RS20790	1251338..1251676	+	339	WP_004748749.1	hypothetical protein	-
IX91_RS20795	1251822..1252064	-	243	WP_004748750.1	hypothetical protein	-
IX91_RS20800	1252106..1252321	-	216	WP_004748751.1	DUF3820 family protein	-
IX91_RS20805	1252334..1253005	-	672	WP_004748752.1	DUF3313 domain-containing protein	-
IX91_RS20810	1253100..1253453	-	354	WP_004748753.1	helix-turn-helix transcriptional regulator	-
IX91_RS20815	1253986..1255443	+	1458	WP_004748754.1	N-acetylglucosamine-binding protein GbpA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11683.46 Da
• Isoelectric Point: 10.5165

>T48784 WP_004748748.1 NZ_CP009355:1250824-1251123 [Vibrio tubiashii ATCC 19109]
VRPFQLTSKAKSDLRDIALFTSRRWGREQRNVYLKQFDESFWLLAENPDIGKACDEIRKGYRKFPQSSHVIFYRQIGSQK
IEIIRILHKSIDVNPIFGA

Nucleotide

• Length: 300 bp

>T48784 NZ_CP009355:1250824-1251123 [Vibrio tubiashii ATCC 19109]
GTGAGACCATTTCAACTAACCAGCAAAGCAAAGTCTGATTTGCGTGATATCGCTTTATTTACTTCACGCCGCTGGGGGCG
TGAACAACGAAATGTTTATTTAAAACAATTTGATGAATCATTTTGGCTGCTAGCTGAAAACCCTGATATTGGTAAAGCTT
GTGACGAAATAAGAAAAGGTTACCGGAAATTCCCACAAAGCAGCCACGTAATATTTTACCGCCAGATCGGCAGTCAAAAA
ATAGAGATCATCCGTATTTTACACAAAAGCATAGATGTCAACCCAATCTTTGGTGCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8983.90 Da
• Isoelectric Point: 4.2213

>AT48784 WP_004748747.1 NZ_CP009355:1250585-1250827 [Vibrio tubiashii ATCC 19109]
MAKNTSITLGDHFDVFIANQVQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGTADYDLDSFINELDSEERK

Nucleotide

• Length: 243 bp

>AT48784 NZ_CP009355:1250585-1250827 [Vibrio tubiashii ATCC 19109]
ATGGCCAAAAACACGAGCATTACTCTTGGCGACCACTTTGATGTATTTATAGCAAATCAAGTTCAAAGCGGTCGATACGG
CTCAGCAAGCGAGGTTATTCGCTCGGCGCTACGCTTACTTGAGACTCAAGAAACTAAAATGAACACTTTAAGGCAACTAC
TCGTAGAAGGCGAAGAAAGTGGAACTGCTGACTATGACCTTGATTCGTTTATCAATGAGCTAGATAGCGAAGAAAGAAAG
TGA

Structures

Toxin

• AlphaFold DB: F9TDA0

Antitoxin

• AlphaFold DB: F9TD99