48783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3630335..3630977 Replicon chromosome
Accession NZ_CP009351
Organism Bacillus thuringiensis HD1002

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag AS86_RS24210 Protein ID WP_000635965.1
Coordinates 3630335..3630685 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag AS86_RS24215 Protein ID WP_000004570.1
Coordinates 3630690..3630977 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS86_RS24195 3627271..3627729 - 459 WP_000343552.1 SprT family protein -
AS86_RS35720 3627925..3628041 + 117 WP_001143640.1 cortex morphogenetic protein CmpA -
AS86_RS24205 3628099..3630267 - 2169 WP_000426211.1 RNA-binding transcriptional accessory protein -
AS86_RS24210 3630335..3630685 - 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AS86_RS24215 3630690..3630977 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
AS86_RS24220 3631286..3632455 - 1170 WP_000390594.1 alanine racemase -
AS86_RS24225 3632573..3633523 - 951 WP_003309006.1 outer membrane lipoprotein carrier protein LolA -
AS86_RS24230 3633680..3634039 - 360 WP_000583420.1 holo-ACP synthase -
AS86_RS24235 3634133..3634705 + 573 WP_000908528.1 rhomboid family intramembrane serine protease -
AS86_RS24240 3634698..3635660 - 963 WP_000961146.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T48783 WP_000635965.1 NZ_CP009351:c3630685-3630335 [Bacillus thuringiensis HD1002]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T48783 NZ_CP009351:c3630685-3630335 [Bacillus thuringiensis HD1002]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTAGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT48783 WP_000004570.1 NZ_CP009351:c3630977-3630690 [Bacillus thuringiensis HD1002]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT48783 NZ_CP009351:c3630977-3630690 [Bacillus thuringiensis HD1002]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTATATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCG
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References