Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 4843985..4844960 Replicon chromosome
Accession NZ_CP009341
Organism Bacillus anthracis strain Ohio ACB

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BG02_RS27245 Protein ID WP_002036394.1
Coordinates 4843985..4844722 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BG02_RS27250 Protein ID WP_000588712.1
Coordinates 4844835..4844960 (+) Length 42 a.a.

Genomic Context


BG02_RS27225BG02_RS27235BG02_RS27240BG02_RS27245BG02_RS27250BG02_RS32275BG02_RS32280BG02_RS27275BG02_RS27230BG02_RS27260BG02_RS27265BG02_RS27280
Location: 4839713..4840495 (783 bp)
Type: Others
Protein ID: WP_000381787.1
Location: 4842409..4842891 (483 bp)
Type: Others
Protein ID: WP_000191911.1
Location: 4843059..4843796 (738 bp)
Type: Others
Protein ID: WP_000594139.1
Location: 4843985..4844722 (738 bp)
Type: Toxin
Protein ID: WP_002036394.1
Location: 4844835..4844960 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 4845037..4845213 (177 bp)
Type: Others
Protein ID: WP_000852614.1
Location: 4846383..4846559 (177 bp)
Type: Others
Protein ID: WP_000808045.1
Location: 4846703..4848172 (1470 bp)
Type: Others
Protein ID: WP_000287522.1
Location: 4840617..4842302 (1686 bp)
Type: Others
Protein ID: WP_009879073.1
Location: 4845250..4845531 (282 bp)
Type: Others
Protein ID: WP_001041555.1
Location: 4845808..4846044 (237 bp)
Type: Others
Protein ID: WP_001021689.1
Location: 4848736..4849206 (471 bp)
Type: Others
Protein ID: WP_000670597.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG02_RS272254839713..4840495+783WP_000381787.1class I SAM-dependent methyltransferase-
BG02_RS272304840617..4842302-1686WP_009879073.1alpha-keto acid decarboxylase family protein-
BG02_RS272354842409..4842891+483WP_000191911.1MarR family winged helix-turn-helix transcriptional regulator-
BG02_RS272404843059..4843796+738WP_000594139.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
BG02_RS272454843985..4844722+738WP_002036394.1type II toxin-antitoxin system SpoIISA family toxinToxin
BG02_RS272504844835..4844960+126WP_000588712.1hypothetical proteinAntitoxin
BG02_RS322754845037..4845213+177WP_000852614.1hypothetical protein-
BG02_RS272604845250..4845531-282WP_001041555.1hypothetical protein-
BG02_RS272654845808..4846044-237WP_001021689.1hypothetical protein-
BG02_RS322804846383..4846559+177WP_000808045.1hypothetical protein-
BG02_RS272754846703..4848172+1470WP_000287522.1beta-Ala-His dipeptidase-
BG02_RS272804848736..4849206-471WP_000670597.1DUF5065 family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-243)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T48781 WP_002036394.1 NZ_CP009341:4843985-4844722 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T48781 NZ_CP009341:4843985-4844722 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT48781 WP_000588712.1 NZ_CP009341:4844835-4844960 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT48781 NZ_CP009341:4844835-4844960 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A2R2IKP2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References