Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3537990..3538965 Replicon chromosome
Accession NZ_CP009335
Organism Bacillus thuringiensis strain HD1011

Toxin (Protein)


Gene name spoIISA Uniprot ID C3GJ28
Locus tag BF38_RS21660 Protein ID WP_003297560.1
Coordinates 3537990..3538727 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BF38_RS21665 Protein ID WP_000588712.1
Coordinates 3538840..3538965 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF38_RS21635 3533522..3533929 + 408 WP_000072501.1 VOC family protein -
BF38_RS21640 3534190..3534500 + 311 Protein_3526 hypothetical protein -
BF38_RS21645 3534622..3536307 - 1686 WP_003297558.1 alpha-keto acid decarboxylase family protein -
BF38_RS21650 3536414..3536896 + 483 WP_000191912.1 MarR family winged helix-turn-helix transcriptional regulator -
BF38_RS21655 3537064..3537801 + 738 WP_000594156.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF38_RS21660 3537990..3538727 + 738 WP_003297560.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF38_RS21665 3538840..3538965 + 126 WP_000588712.1 hypothetical protein Antitoxin
BF38_RS21675 3539253..3539534 - 282 WP_001041555.1 hypothetical protein -
BF38_RS34245 3539969..3540145 + 177 WP_000808045.1 hypothetical protein -
BF38_RS21685 3540289..3541758 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BF38_RS21690 3542322..3542792 - 471 WP_000670597.1 DUF5065 family protein -
BF38_RS21695 3542969..3543589 + 621 WP_002036390.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.07 Da        Isoelectric Point: 8.2672

>T48776 WP_003297560.1 NZ_CP009335:3537990-3538727 [Bacillus thuringiensis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T48776 NZ_CP009335:3537990-3538727 [Bacillus thuringiensis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT48776 WP_000588712.1 NZ_CP009335:3538840-3538965 [Bacillus thuringiensis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT48776 NZ_CP009335:3538840-3538965 [Bacillus thuringiensis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9EK80

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References