Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1109317..1110292 Replicon chromosome
Accession NZ_CP009328
Organism Bacillus anthracis strain Vollum 1B

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BF39_RS07240 Protein ID WP_002036394.1
Coordinates 1109317..1110054 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BF39_RS07245 Protein ID WP_000588712.1
Coordinates 1110167..1110292 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF39_RS07220 1105045..1105827 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
BF39_RS07225 1105949..1107634 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
BF39_RS07230 1107741..1108223 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BF39_RS07235 1108391..1109128 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BF39_RS07240 1109317..1110054 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BF39_RS07245 1110167..1110292 + 126 WP_000588712.1 hypothetical protein Antitoxin
BF39_RS32010 1110369..1110545 + 177 WP_000852614.1 hypothetical protein -
BF39_RS07255 1110582..1110863 - 282 WP_001041555.1 hypothetical protein -
BF39_RS07260 1111140..1111376 - 237 WP_001021689.1 hypothetical protein -
BF39_RS32015 1111715..1111891 + 177 WP_000808045.1 hypothetical protein -
BF39_RS07270 1112035..1113504 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BF39_RS07275 1114068..1114538 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T48771 WP_002036394.1 NZ_CP009328:1109317-1110054 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T48771 NZ_CP009328:1109317-1110054 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT48771 WP_000588712.1 NZ_CP009328:1110167-1110292 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT48771 NZ_CP009328:1110167-1110292 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References