Detailed information of TA system TA048767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3883476..3884051
• Replicon: chromosome
• Accession: NZ_CP009322
• Organism: Burkholderia gladioli strain ATCC 10248

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BM43_RS16695
• Protein ID: WP_036054553.1
• Coordinates: 3883764..3884051 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A560UNM0
• Locus tag: BM43_RS16690
• Protein ID: WP_036030606.1
• Coordinates: 3883476..3883760 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BM43_RS16670	3878574..3879857	-	1284	WP_013689299.1	4-aminobutyrate--2-oxoglutarate transaminase	-
BM43_RS16675	3879993..3881630	+	1638	WP_036054559.1	PLP-dependent aminotransferase family protein	-
BM43_RS16680	3881816..3882943	+	1128	WP_167547494.1	ABC transporter substrate-binding protein	-
BM43_RS16685	3883092..3883418	+	327	WP_036054555.1	hypothetical protein	-
BM43_RS16690	3883476..3883760	-	285	WP_036030606.1	putative addiction module antidote protein	Antitoxin
BM43_RS16695	3883764..3884051	-	288	WP_036054553.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BM43_RS16700	3884184..3885122	-	939	WP_036054551.1	2-dehydropantoate 2-reductase	-
BM43_RS16705	3885279..3885749	+	471	WP_013689305.1	Lrp/AsnC family transcriptional regulator	-
BM43_RS16710	3885793..3886629	-	837	WP_036054549.1	DMT family transporter	-
BM43_RS16715	3886874..3887935	+	1062	WP_013689307.1	selenide, water dikinase SelD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (5-94)

Antitoxin

• Uncharacterized protein HI1420 (11-89)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10959.72 Da
• Isoelectric Point: 10.4966

>T48767 WP_036054553.1 NZ_CP009322:c3884051-3883764 [Burkholderia gladioli]
MLRSSEFTNWLSSLRDQRGKARIAARLISAQLGNFGEYRVIGEGVREMKVDFGPGYRIYYVRRAEIVYVLLCGGDKSTQK
KDIKRALQMARELKE

Nucleotide

• Length: 288 bp

>T48767 NZ_CP009322:c3884051-3883764 [Burkholderia gladioli]
TTGCTGCGCTCCAGTGAATTCACAAACTGGCTTTCCAGCCTGCGTGATCAGCGCGGCAAAGCCCGAATCGCCGCACGCCT
GATCAGTGCCCAGCTAGGCAATTTTGGCGAGTACCGCGTGATAGGCGAAGGCGTCCGCGAAATGAAGGTCGACTTCGGGC
CGGGTTATCGCATCTACTATGTCCGTCGCGCCGAGATCGTCTATGTCCTTCTCTGCGGTGGCGATAAATCTACACAGAAA
AAAGACATCAAGCGCGCGCTCCAGATGGCGCGCGAACTGAAGGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10072.47 Da
• Isoelectric Point: 5.0484

>AT48767 WP_036030606.1 NZ_CP009322:c3883760-3883476 [Burkholderia gladioli]
MPDYAEFDAADYLDNDETVAEFLAVAAEDPDPAVFLAAVAAVARARGMTKVASEAGLGRVTLHKALTPGAHPRYETVQKI
LRSLGLRMTFTVAH

Nucleotide

• Length: 285 bp

>AT48767 NZ_CP009322:c3883760-3883476 [Burkholderia gladioli]
ATGCCCGATTACGCCGAATTCGATGCGGCCGACTATCTCGACAATGACGAAACCGTGGCGGAATTTCTCGCGGTTGCGGC
AGAGGATCCCGATCCCGCAGTGTTCCTTGCTGCCGTGGCCGCTGTCGCACGCGCGCGCGGGATGACCAAGGTGGCGTCGG
AAGCCGGCCTTGGACGGGTCACCTTGCACAAGGCGCTGACGCCTGGCGCTCACCCTCGATATGAGACCGTGCAGAAGATC
CTGCGCTCGCTGGGCCTTCGCATGACCTTCACCGTCGCCCACTGA

Structures

Antitoxin

• AlphaFold DB: A0A560UNM0