Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 54578..55170 Replicon plasmid 2
Accession NZ_CP009320
Organism Burkholderia gladioli strain ATCC 10248

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag BM43_RS37985 Protein ID WP_036057804.1
Coordinates 54877..55170 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag BM43_RS00370 Protein ID WP_080752326.1
Coordinates 54578..54874 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM43_RS00350 52510..53331 + 822 WP_144417599.1 HNH endonuclease -
BM43_RS00355 53339..53818 + 480 WP_052710549.1 conjugal transfer protein TraD -
BM43_RS00360 53926..54324 + 399 WP_052710550.1 hypothetical protein -
BM43_RS00365 54321..54581 + 261 WP_036057801.1 hypothetical protein -
BM43_RS00370 54578..54874 - 297 WP_080752326.1 putative addiction module antidote protein Antitoxin
BM43_RS37985 54877..55170 - 294 WP_036057804.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM43_RS00380 55245..57275 - 2031 WP_158380916.1 ParB/Srx family N-terminal domain-containing protein -
BM43_RS00385 57489..57845 + 357 WP_045577423.1 antirestriction protein -
BM43_RS00390 58103..58315 + 213 WP_036057807.1 DUF3717 domain-containing protein -
BM43_RS41550 58693..58965 + 273 WP_080752327.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..63573 63573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10865.36 Da        Isoelectric Point: 9.6552

>T48763 WP_036057804.1 NZ_CP009320:c55170-54877 [Burkholderia gladioli]
MVIEQTDDFAKWLRGLRDHIARAQIAKRIQRLAHGQYGDVKSVGAGVSELRVHTGPGYRVYFAQRGSTIIVLLCGGDKST
QQRDIQRAWALASELEE

Download         Length: 294 bp

>T48763 NZ_CP009320:c55170-54877 [Burkholderia gladioli]
ATGGTAATCGAACAGACAGACGATTTTGCGAAGTGGCTGCGCGGATTGCGCGACCACATCGCGCGTGCGCAAATCGCCAA
ACGGATTCAACGACTCGCCCACGGGCAGTATGGCGATGTCAAGTCGGTCGGCGCTGGTGTTAGCGAGTTACGGGTTCATA
CAGGGCCAGGATACAGGGTGTATTTCGCGCAGCGTGGTTCCACGATCATTGTGCTGCTGTGCGGCGGCGATAAATCCACT
CAGCAAAGAGATATTCAACGAGCATGGGCGCTTGCGTCCGAATTGGAGGAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10500.76 Da        Isoelectric Point: 4.3867

>AT48763 WP_080752326.1 NZ_CP009320:c54874-54578 [Burkholderia gladioli]
MAIKTTPFDPADYLDSPEAQTEYLRESFESGDSADIQEAIGTVARARGMAQVALAAGVGRQSLYKALDERGNPEFATILS
VVRALGLNLTVTPTQRQA

Download         Length: 297 bp

>AT48763 NZ_CP009320:c54874-54578 [Burkholderia gladioli]
ATGGCAATCAAGACGACACCATTCGACCCAGCGGATTATCTCGACTCGCCCGAGGCGCAAACGGAATATCTCCGCGAGTC
GTTTGAATCCGGAGACTCGGCCGACATCCAAGAAGCGATCGGAACGGTTGCCCGAGCGCGGGGCATGGCTCAGGTCGCTC
TAGCGGCAGGCGTTGGCCGACAAAGCTTGTACAAGGCGCTGGACGAACGTGGCAATCCCGAGTTCGCAACGATCCTGAGC
GTTGTTCGAGCGCTCGGCCTCAACCTCACTGTCACGCCAACACAACGTCAAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References