Detailed information of TA system TA048756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 1984253..1985228
• Replicon: chromosome
• Accession: NZ_CP009300
• Organism: Bacillus cereus D17

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: AW22_RS11585
• Protein ID: WP_052494343.1
• Coordinates: 1984491..1985228 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: C2VTW9
• Locus tag: AW22_RS11580
• Protein ID: WP_000588936.1
• Coordinates: 1984253..1984378 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AW22_RS11550	1979609..1980229	-	621	WP_127813147.1	SGNH/GDSL hydrolase family protein	-
AW22_RS11555	1980406..1980876	+	471	WP_000670597.1	DUF5065 family protein	-
AW22_RS11560	1981458..1982927	-	1470	WP_042512696.1	beta-Ala-His dipeptidase	-
AW22_RS31500	1983071..1983247	-	177	WP_042512697.1	hypothetical protein	-
AW22_RS11570	1983682..1983963	+	282	WP_001041554.1	hypothetical protein	-
AW22_RS31505	1984000..1984176	-	177	WP_042512698.1	hypothetical protein	-
AW22_RS11580	1984253..1984378	-	126	WP_000588936.1	hypothetical protein	Antitoxin
AW22_RS11585	1984491..1985228	-	738	WP_052494343.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
AW22_RS11590	1985417..1986154	-	738	WP_042512700.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
AW22_RS11595	1986322..1986804	-	483	WP_042512701.1	MarR family winged helix-turn-helix transcriptional regulator	-
AW22_RS11600	1986911..1987693	+	783	Protein_2080	alpha-keto acid decarboxylase family protein	-
AW22_RS11605	1988013..1988897	-	885	WP_042512702.1	hypothetical protein	-
AW22_RS11610	1989020..1989721	-	702	WP_001294994.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1961155..2089107	127952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28358.10 Da
• Isoelectric Point: 8.9957

>T48756 WP_052494343.1 NZ_CP009300:c1985228-1984491 [Bacillus cereus D17]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T48756 NZ_CP009300:c1985228-1984491 [Bacillus cereus D17]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4888.29 Da
• Isoelectric Point: 3.9798

>AT48756 WP_000588936.1 NZ_CP009300:c1984378-1984253 [Bacillus cereus D17]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK

Nucleotide

• Length: 126 bp

>AT48756 NZ_CP009300:c1984378-1984253 [Bacillus cereus D17]
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: C2VTW9