Detailed information of TA system TA048748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-CC2985
• Location: 1704441..1705003
• Replicon: chromosome
• Accession: NZ_CP009291
• Organism: Novosphingobium pentaromativorans US6-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G6EDG6
• Locus tag: JI59_RS07855
• Protein ID: WP_007013302.1
• Coordinates: 1704441..1704734 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JI59_RS07860
• Protein ID: WP_038575778.1
• Coordinates: 1704734..1705003 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JI59_RS07820	1699957..1700190	+	234	Protein_1562	hypothetical protein	-
JI59_RS07825	1700424..1701404	-	981	WP_007013308.1	DUF2493 domain-containing protein	-
JI59_RS07830	1701816..1702058	-	243	WP_007013307.1	hypothetical protein	-
JI59_RS07835	1702127..1703125	-	999	WP_007013306.1	DUF2493 domain-containing protein	-
JI59_RS07840	1703220..1703681	-	462	WP_007013305.1	DUF736 domain-containing protein	-
JI59_RS27360	1703884..1704093	+	210	WP_038575777.1	hypothetical protein	-
JI59_RS07850	1704163..1704375	-	213	WP_007013303.1	hypothetical protein	-
JI59_RS07855	1704441..1704734	-	294	WP_007013302.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JI59_RS07860	1704734..1705003	-	270	WP_038575778.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JI59_RS07865	1705369..1705974	-	606	Protein_1571	hypothetical protein	-
JI59_RS07870	1706078..1706542	-	465	WP_138921373.1	hypothetical protein	-
JI59_RS07875	1706520..1708328	-	1809	WP_007013298.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Antitoxin ParD (3-67)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10792.30 Da
• Isoelectric Point: 6.2147

>T48748 WP_007013302.1 NZ_CP009291:c1704734-1704441 [Novosphingobium pentaromativorans US6-1]
MHLQFSPAAEADLVDIAAFIARDNVPRAFTFVDELEAACARLVDFPESGSARFDLRPGLRSRPHGSYVIFYSTLDRVIRI
ERILHGARDVGAILFSS

Nucleotide

• Length: 294 bp

>T48748 NZ_CP009291:c1704734-1704441 [Novosphingobium pentaromativorans US6-1]
ATGCATCTGCAGTTTTCGCCCGCGGCGGAAGCAGACCTTGTCGATATTGCCGCCTTCATCGCTCGCGACAATGTTCCGCG
GGCTTTCACCTTTGTTGACGAACTTGAAGCGGCATGTGCCAGGCTTGTCGATTTCCCCGAGTCCGGGAGTGCTCGTTTCG
ACCTTCGTCCCGGGCTGCGCTCCAGACCGCACGGTAGCTATGTGATCTTCTACAGCACCCTGGACAGGGTCATCCGTATT
GAGCGTATTCTGCATGGGGCCCGCGATGTCGGCGCGATCCTCTTTTCCAGTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9528.62 Da
• Isoelectric Point: 6.4653

>AT48748 WP_038575778.1 NZ_CP009291:c1705003-1704734 [Novosphingobium pentaromativorans US6-1]
MPSSFTLGAHFEGFIKSQVNSGRYASASEVVRDSLRLLEEQDAMRQARLDALRAEIEHGAASGPGIPAEQAFANARKRIA
DIAAAARDS

Nucleotide

• Length: 270 bp

>AT48748 NZ_CP009291:c1705003-1704734 [Novosphingobium pentaromativorans US6-1]
ATGCCTTCCAGCTTTACCTTGGGTGCCCATTTCGAGGGCTTCATCAAGAGCCAGGTGAACAGCGGTCGCTACGCGTCCGC
CAGCGAGGTCGTTCGCGATAGCCTCCGCTTGCTCGAGGAACAGGACGCCATGCGTCAGGCCCGGCTCGACGCGCTCCGCG
CCGAGATCGAGCATGGTGCGGCCAGCGGTCCGGGCATTCCCGCTGAGCAGGCATTCGCGAACGCACGCAAGCGGATCGCT
GATATCGCCGCCGCCGCCAGGGATAGTTGA

Structures

Toxin

• AlphaFold DB: G6EDG6