Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6366560..6367173 Replicon chromosome
Accession NZ_CP009290
Organism Pseudomonas chlororaphis subsp. aurantiaca strain JD37

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7J8U8
Locus tag JM49_RS28560 Protein ID WP_038583007.1
Coordinates 6366991..6367173 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag JM49_RS28555 Protein ID WP_009046450.1
Coordinates 6366560..6366961 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM49_RS28530 6362108..6362947 + 840 WP_038583001.1 taurine ABC transporter permease TauC -
JM49_RS28535 6363175..6364014 + 840 WP_038583002.1 taurine dioxygenase -
JM49_RS28540 6364154..6364399 + 246 WP_009046453.1 plasmid stabilization protein -
JM49_RS28545 6364396..6364824 + 429 WP_038583004.1 type II toxin-antitoxin system VapC family toxin -
JM49_RS28550 6364954..6365991 - 1038 WP_038583005.1 L-glyceraldehyde 3-phosphate reductase -
JM49_RS28555 6366560..6366961 - 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JM49_RS28560 6366991..6367173 - 183 WP_038583007.1 type II toxin-antitoxin system HicA family toxin Toxin
JM49_RS28565 6367298..6368188 - 891 WP_009046449.1 LysR family transcriptional regulator -
JM49_RS28570 6368318..6369058 + 741 WP_016702555.1 SDR family oxidoreductase -
JM49_RS28575 6369115..6369603 + 489 WP_038583009.1 DoxX family protein -
JM49_RS28580 6369656..6369913 + 258 WP_038583011.1 hypothetical protein -
JM49_RS28585 6370029..6371993 - 1965 WP_172667010.1 choline transporter BetT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6874.01 Da        Isoelectric Point: 10.4588

>T48746 WP_038583007.1 NZ_CP009290:c6367173-6366991 [Pseudomonas chlororaphis subsp. aurantiaca]
MRSRELIRMIEEDGWYLIAAKGSHHPYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T48746 NZ_CP009290:c6367173-6366991 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCAGCCAAAGGCAGTCATCACCCGTA
CAAACATCTGCATAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT48746 WP_009046450.1 NZ_CP009290:c6366961-6366560 [Pseudomonas chlororaphis subsp. aurantiaca]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT48746 NZ_CP009290:c6366961-6366560 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAAGCCCTGTCGCTGCATTACGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGATTACGCCGGTGGCGTGTGGGGCGTGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGTTTCAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGCTTTCTCGCGGCAGCGGCATTGCGCGAACTCTCCGCCT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7J8U8

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References