Detailed information of TA system TA048745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 6364154..6364824
• Replicon: chromosome
• Accession: NZ_CP009290
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain JD37

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JM49_RS28545
• Protein ID: WP_038583004.1
• Coordinates: 6364396..6364824 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: JM49_RS28540
• Protein ID: WP_009046453.1
• Coordinates: 6364154..6364399 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM49_RS28520	6360244..6361221	+	978	WP_038582998.1	taurine ABC transporter substrate-binding protein	-
JM49_RS28525	6361317..6362111	+	795	WP_038583000.1	taurine ABC transporter ATP-binding subunit	-
JM49_RS28530	6362108..6362947	+	840	WP_038583001.1	taurine ABC transporter permease TauC	-
JM49_RS28535	6363175..6364014	+	840	WP_038583002.1	taurine dioxygenase	-
JM49_RS28540	6364154..6364399	+	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
JM49_RS28545	6364396..6364824	+	429	WP_038583004.1	type II toxin-antitoxin system VapC family toxin	Toxin
JM49_RS28550	6364954..6365991	-	1038	WP_038583005.1	L-glyceraldehyde 3-phosphate reductase	-
JM49_RS28555	6366560..6366961	-	402	WP_009046450.1	type II toxin-antitoxin system HicB family antitoxin	-
JM49_RS28560	6366991..6367173	-	183	WP_038583007.1	type II toxin-antitoxin system HicA family toxin	-
JM49_RS28565	6367298..6368188	-	891	WP_009046449.1	LysR family transcriptional regulator	-
JM49_RS28570	6368318..6369058	+	741	WP_016702555.1	SDR family oxidoreductase	-
JM49_RS28575	6369115..6369603	+	489	WP_038583009.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15855.33 Da
• Isoelectric Point: 5.4927

>T48745 WP_038583004.1 NZ_CP009290:6364396-6364824 [Pseudomonas chlororaphis subsp. aurantiaca]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFTDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Nucleotide

• Length: 429 bp

>T48745 NZ_CP009290:6364396-6364824 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCTATGACCATGGCCGAGATTCTCCACGGTATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCCATGTTCGAGGAAGACTTCACCGACCGCATCGTGCCCTTCGGAACC
CAAGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAATCTGGTGGATGCGCAAAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT48745 WP_009046453.1 NZ_CP009290:6364154-6364399 [Pseudomonas chlororaphis subsp. aurantiaca]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT48745 NZ_CP009290:6364154-6364399 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGGCCAGCCTTACGATCCGTAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGCTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9