Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5124013..5124541 Replicon chromosome
Accession NZ_CP009290
Organism Pseudomonas chlororaphis subsp. aurantiaca strain JD37

Toxin (Protein)


Gene name relE Uniprot ID A0A7S5LMJ4
Locus tag JM49_RS22850 Protein ID WP_038581545.1
Coordinates 5124242..5124541 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S5HLJ1
Locus tag JM49_RS22845 Protein ID WP_038581543.1
Coordinates 5124013..5124252 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM49_RS22815 5119041..5119913 + 873 WP_038583918.1 phosphotransferase -
JM49_RS22820 5120098..5120496 + 399 WP_038581536.1 low affinity iron permease family protein -
JM49_RS22825 5120579..5121103 - 525 WP_038581538.1 DUF4142 domain-containing protein -
JM49_RS22830 5121242..5122582 - 1341 WP_038581539.1 sensor domain-containing diguanylate cyclase -
JM49_RS22835 5122694..5123332 - 639 WP_023968117.1 LysE family translocator -
JM49_RS22840 5123460..5123876 - 417 WP_038581541.1 fosfomycin resistance glutathione transferase -
JM49_RS22845 5124013..5124252 + 240 WP_038581543.1 ribbon-helix-helix protein, CopG family Antitoxin
JM49_RS22850 5124242..5124541 + 300 WP_038581545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JM49_RS22855 5124615..5125763 - 1149 WP_038581547.1 L-threonine dehydrogenase -
JM49_RS22860 5125921..5126940 + 1020 WP_009047445.1 DUF4917 family protein -
JM49_RS22865 5127259..5127801 - 543 WP_007922237.1 XRE family transcriptional regulator -
JM49_RS22870 5127961..5128743 + 783 WP_023968112.1 aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11487.13 Da        Isoelectric Point: 10.8916

>T48743 WP_038581545.1 NZ_CP009290:5124242-5124541 [Pseudomonas chlororaphis subsp. aurantiaca]
MHVEWLRSALKNLDDEAAYIAQDSPQAAAEFVKAILSSIQHLSRFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGWQDDRQ

Download         Length: 300 bp

>T48743 NZ_CP009290:5124242-5124541 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGCACGTTGAGTGGCTGCGCAGCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAGGACAGTCCTCAGGC
CGCCGCGGAATTCGTCAAAGCCATCCTGAGTAGCATTCAACACCTGAGCCGTTTTCCTGCCAGTGGTCGCGAAGGTCGCC
TGCCCGGTACCCGGGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCACACCCGGCGCTTGCCGCCTGCCGGTTGGCAAGACGACCGCCAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8648.73 Da        Isoelectric Point: 4.5535

>AT48743 WP_038581543.1 NZ_CP009290:5124013-5124252 [Pseudomonas chlororaphis subsp. aurantiaca]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQINEIQKALTEAEAGDFASAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT48743 NZ_CP009290:5124013-5124252 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCACTGAGAGAATATCTGGCCCGCGAAGCCTGGCAAATCAACGAGATCCAGAAAGCCCTGA
CTGAAGCAGAGGCAGGCGACTTCGCCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5LMJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7S5HLJ1

References