Detailed information of TA system TA048741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2694843..2695362
• Replicon: chromosome
• Accession: NZ_CP009290
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain JD37

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JM49_RS12235
• Protein ID: WP_038578025.1
• Coordinates: 2695081..2695362 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H3UB71
• Locus tag: JM49_RS12230
• Protein ID: WP_009044432.1
• Coordinates: 2694843..2695091 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM49_RS12210	2690364..2690825	-	462	WP_009049642.1	YccF domain-containing protein	-
JM49_RS12215	2690898..2692661	-	1764	WP_038578019.1	hypothetical protein	-
JM49_RS12220	2692876..2693874	-	999	WP_038578020.1	bile acid:sodium symporter	-
JM49_RS12225	2693959..2694747	+	789	WP_038578022.1	helix-turn-helix transcriptional regulator	-
JM49_RS12230	2694843..2695091	+	249	WP_009044432.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JM49_RS12235	2695081..2695362	+	282	WP_038578025.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JM49_RS12240	2695540..2697189	-	1650	WP_038578026.1	FMN-binding glutamate synthase family protein	-
JM49_RS12245	2697246..2697728	-	483	WP_038578027.1	acyl-CoA thioesterase	-
JM49_RS12250	2698105..2698677	-	573	WP_038578028.1	glutamine amidotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10794.60 Da
• Isoelectric Point: 10.5816

>T48741 WP_038578025.1 NZ_CP009290:2695081-2695362 [Pseudomonas chlororaphis subsp. aurantiaca]
MTYELEFSEKAWKEWQKLGPTLKEQFKKKLQERLVNPHVPADRLSGLGSAYKIKLRTAGYRLVYRVVDEVLVVTVIAVGK
RERGSVYQQASKR

Nucleotide

• Length: 282 bp

>T48741 NZ_CP009290:2695081-2695362 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTCCCGGCCGATCGCCTGAGCGGTTTGGGCAGTGCCTACAAAATCA
AACTGCGCACGGCGGGTTACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGTCATTGCCGTGGGCAAG
CGAGAGCGGGGGAGTGTCTATCAGCAAGCCAGCAAGCGTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8997.37 Da
• Isoelectric Point: 4.4142

>AT48741 WP_009044432.1 NZ_CP009290:2694843-2695091 [Pseudomonas chlororaphis subsp. aurantiaca]
MTHVLLSNVVASISELKKNPMGTVAAGGGSSVAILNRNEPAFYCVPAKEYEAMMERLEDMELLALCRERENDPTIKVSLD
DL

Nucleotide

• Length: 249 bp

>AT48741 NZ_CP009290:2694843-2695091 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGACCCATGTCCTTCTGTCCAACGTCGTTGCGAGCATTTCCGAGCTCAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGTGGTTCCTCCGTGGCTATCCTCAATCGCAACGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGTCTGGAAGATATGGAGCTGCTCGCCTTGTGCCGTGAACGAGAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A1H3UB71