Detailed information of TA system TA048738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1481458..1482063
• Replicon: chromosome
• Accession: NZ_CP009288
• Organism: Paenibacillus durus strain DSM 1735

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A0F7CHC6
• Locus tag: PDUR_RS06695
• Protein ID: WP_025691534.1
• Coordinates: 1481713..1482063 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: PDUR_RS06690
• Protein ID: WP_175491834.1
• Coordinates: 1481458..1481709 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PDUR_RS06665	1476783..1476971	-	189	WP_042205592.1	DUF86 domain-containing protein	-
PDUR_RS06675	1477834..1478295	+	462	WP_042205593.1	hypothetical protein	-
PDUR_RS06680	1478719..1479807	+	1089	WP_042205594.1	outer membrane lipoprotein carrier protein LolA	-
PDUR_RS06685	1480032..1481234	+	1203	WP_042205595.1	alanine racemase	-
PDUR_RS06690	1481458..1481709	+	252	WP_175491834.1	ribbon-helix-helix protein, CopG family	Antitoxin
PDUR_RS06695	1481713..1482063	+	351	WP_025691534.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
PDUR_RS06700	1482264..1484450	+	2187	WP_179945198.1	RNA-binding transcriptional accessory protein	-
PDUR_RS06705	1484595..1485578	-	984	WP_042205596.1	S-layer homology domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-35)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12796.68 Da
• Isoelectric Point: 5.1171

>T48738 WP_025691534.1 NZ_CP009288:1481713-1482063 [Paenibacillus durus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDASSHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDDSLQISLGLIDF

Nucleotide

• Length: 351 bp

>T48738 NZ_CP009288:1481713-1482063 [Paenibacillus durus]
TTGATCGTAAAACGCGGCGATGTTTTCTTTGCCGATCTTTCGCCGGTAGTTGGTTCCGAGCAGGGCGGAGTAAGGCCTGT
TCTCGTCATTCAGAACGATATTGGCAATCGCTTTAGTCCAACGGTAATTGTTGCGGCAATTACCGCACAGATCCAGAAGG
CCAAGCTGCCAACTCATGTGGAAATTGACGCGTCATCCCACGGCTTTGACCGGGATTCCGTCATTTTGCTGGAACAGGTT
CGGACGATCGACAAGCAGCGCTTGACGGATAAGATCACCCATCTTGACGATGAAACGATGAAAAAGGTGGATGACTCGCT
GCAGATCAGTCTGGGTCTAATTGATTTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9505.98 Da
• Isoelectric Point: 5.1184

>AT48738 WP_175491834.1 NZ_CP009288:1481458-1481709 [Paenibacillus durus]
MISLPDHLLQEVDGIVQMENSNRSELIRQAMKLYLSERRKRSIRESMQRGYMEMAKINLTMACEAFLAEEDADSTLGRLV
SGV

Nucleotide

• Length: 252 bp

>AT48738 NZ_CP009288:1481458-1481709 [Paenibacillus durus]
ATGATCAGCTTGCCCGATCATCTCTTGCAGGAGGTTGACGGAATTGTCCAAATGGAGAATTCCAATCGCAGTGAATTGAT
CCGGCAAGCCATGAAGCTGTATCTCAGCGAACGGAGGAAGCGTTCCATAAGGGAGTCCATGCAGCGCGGATACATGGAAA
TGGCTAAGATCAACTTGACCATGGCATGTGAAGCGTTCCTTGCCGAGGAAGATGCAGACAGTACTCTTGGCCGCTTAGTA
AGCGGGGTGTAG

Structures

Toxin

• AlphaFold DB: A0A0F7CHC6