48734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 819983..820548 Replicon chromosome
Accession NZ_CP009285
Organism Paenibacillus borealis strain DSM 13188

Toxin (Protein)


Gene name mazF Uniprot ID A0A089L3U8
Locus tag PBOR_RS03585 Protein ID WP_042210506.1
Coordinates 820207..820548 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A089L7V5
Locus tag PBOR_RS03580 Protein ID WP_042210505.1
Coordinates 819983..820213 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBOR_RS03555 815552..816130 - 579 WP_042210502.1 DUF1211 domain-containing protein -
PBOR_RS03560 816399..817112 - 714 WP_042210503.1 2OG-Fe(II) oxygenase -
PBOR_RS37520 817105..817650 - 546 WP_081972320.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
PBOR_RS37525 817675..818289 - 615 Protein_685 methylphosphotriester-DNA--protein-cysteine methyltransferase family protein -
PBOR_RS34840 818381..818948 - 568 Protein_686 DNA alkylation repair protein -
PBOR_RS03575 818953..819423 - 471 WP_042210504.1 hypothetical protein -
PBOR_RS36585 819619..819795 + 177 Protein_688 tRNA-dihydrouridine synthase -
PBOR_RS03580 819983..820213 + 231 WP_042210505.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PBOR_RS03585 820207..820548 + 342 WP_042210506.1 endoribonuclease MazF Toxin
PBOR_RS03590 820659..821228 + 570 WP_042210507.1 hypothetical protein -
PBOR_RS03595 821233..822195 + 963 WP_042210508.1 YafY family transcriptional regulator -
PBOR_RS03600 822279..822812 + 534 WP_042210509.1 VOC family protein -
PBOR_RS03605 823106..824128 + 1023 WP_042210510.1 transglycosylase SLT domain-containing protein -
PBOR_RS03610 824280..824897 + 618 WP_042210511.1 glutamine amidotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin

Antitoxin PemI-like

(2-76)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12275.35 Da        Isoelectric Point: 7.8535

>T48734 WP_042210506.1 NZ_CP009285:820207-820548 [Paenibacillus borealis]
MVTGGYVPDRGDLIWLQFHPQAGHEQAGKRPALVVSPASYNGKVGLSLLCPVASKPKGYPFEVVIPQDLPIEGVILADQV
KSLDWQSRQAAFICKVPQSILSDVIAKLDILIR

Download         Length: 342 bp

>T48734 NZ_CP009285:820207-820548 [Paenibacillus borealis]
ATGGTAACGGGCGGGTATGTACCGGATCGGGGTGACTTGATATGGCTGCAGTTCCACCCGCAAGCGGGGCATGAACAGGC
AGGCAAACGCCCGGCCTTGGTCGTGTCTCCTGCTTCTTATAATGGTAAAGTCGGACTTTCCTTGCTCTGTCCGGTAGCTT
CTAAACCAAAGGGCTACCCCTTTGAAGTAGTCATACCGCAGGATCTACCCATTGAAGGGGTTATCCTTGCGGATCAAGTA
AAGAGTCTCGATTGGCAATCCAGACAGGCAGCGTTCATCTGTAAAGTACCACAGAGCATTCTTTCAGATGTCATTGCTAA
GCTGGACATACTGATTCGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8408.53 Da        Isoelectric Point: 4.7469

>AT48734 WP_042210505.1 NZ_CP009285:819983-820213 [Paenibacillus borealis]
MFQVQKWGNSLGIRIPKSLALKVGIEEGSEVDLDVEDGHLIIKPKSATLDEILSRVTPENLHNEVSTGGQQGREIW

Download         Length: 231 bp

>AT48734 NZ_CP009285:819983-820213 [Paenibacillus borealis]
ATGTTTCAGGTTCAGAAATGGGGCAACAGCTTGGGCATTCGCATTCCTAAATCGCTTGCTCTAAAGGTCGGTATTGAGGA
AGGCTCCGAAGTCGATCTTGATGTGGAAGATGGACATCTTATCATCAAGCCGAAGTCGGCCACACTGGACGAAATCCTGT
CCCGGGTCACCCCGGAAAATCTCCATAATGAGGTCTCTACAGGCGGGCAGCAAGGACGGGAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089L3U8

Antitoxin

Source ID Structure
AlphaFold DB A0A089L7V5

References