Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 887122..887687 Replicon chromosome
Accession NZ_CP009280
Organism Paenibacillus sp. FSL P4-0081

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4KHT8
Locus tag P40081_RS03925 Protein ID WP_042133472.1
Coordinates 887346..887687 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U4KHI4
Locus tag P40081_RS03920 Protein ID WP_042133470.1
Coordinates 887122..887352 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P40081_RS03905 882454..884118 - 1665 WP_052421660.1 cellulase family glycosylhydrolase -
P40081_RS03910 884337..885635 - 1299 WP_042133467.1 MFS transporter -
P40081_RS03915 885945..886934 + 990 WP_042133468.1 tRNA-dihydrouridine synthase -
P40081_RS03920 887122..887352 + 231 WP_042133470.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P40081_RS03925 887346..887687 + 342 WP_042133472.1 endoribonuclease MazF Toxin
P40081_RS03930 887798..888367 + 570 WP_042133474.1 hypothetical protein -
P40081_RS03935 888433..889122 - 690 WP_042140728.1 response regulator transcription factor -
P40081_RS03940 889122..891284 - 2163 WP_042133476.1 hypothetical protein -
P40081_RS03945 891504..892526 + 1023 WP_042133477.1 transglycosylase SLT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-111)

Antitoxin

SpoVT-AbrB domain

(5-47)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12242.27 Da        Isoelectric Point: 7.8208

>T48727 WP_042133472.1 NZ_CP009280:887346-887687 [Paenibacillus sp. FSL P4-0081]
MVTGGYVPDRGDLIWLQFNPQAGHEQAGKRPALVVSPASYNGKVGLSLLCPVTSKPKGYPFEVVIPQDLPIEGVILADQV
KSLDWQSKQAAFICKVPQSILSDVTAKLDILIR

Download         Length: 342 bp

>T48727 NZ_CP009280:887346-887687 [Paenibacillus sp. FSL P4-0081]
ATGGTAACGGGCGGGTATGTGCCGGATCGGGGTGACTTGATATGGCTGCAGTTCAACCCGCAAGCGGGGCATGAACAGGC
AGGCAAACGCCCGGCTTTGGTCGTATCTCCTGCTTCTTATAATGGTAAAGTCGGACTTTCGTTGCTCTGTCCGGTAACTT
CTAAACCAAAGGGCTACCCGTTTGAAGTAGTCATACCGCAGGATCTGCCCATTGAAGGGGTTATCCTTGCAGATCAAGTA
AAGAGTCTCGATTGGCAATCCAAGCAGGCAGCGTTCATCTGTAAAGTACCACAGAGCATTCTTTCAGATGTCACTGCTAA
ACTCGACATACTGATTCGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8466.57 Da        Isoelectric Point: 4.5800

>AT48727 WP_042133470.1 NZ_CP009280:887122-887352 [Paenibacillus sp. FSL P4-0081]
MFQVQKWGNSLGIRIPKSLALKVGIEEGSEVDLDVEDGHLIIKPKSATLDELLSRVTPENLHNEVSTGEQQGREVW

Download         Length: 231 bp

>AT48727 NZ_CP009280:887122-887352 [Paenibacillus sp. FSL P4-0081]
ATGTTTCAGGTTCAGAAATGGGGCAACAGCTTGGGCATTCGCATTCCGAAATCCCTTGCTCTAAAGGTCGGTATTGAGGA
AGGCTCCGAAGTCGATCTTGATGTGGAAGATGGACATCTTATCATCAAGCCGAAGTCGGCCACACTGGACGAACTCCTGT
CCCGGGTCACCCCGGAAAATCTCCATAATGAGGTCTCTACAGGCGAGCAGCAGGGACGGGAAGTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4KHT8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4KHI4

References