Detailed information of TA system TA048726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1285949..1286554
• Replicon: chromosome
• Accession: NZ_CP009279
• Organism: Paenibacillus sp. FSL H7-0737

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A0W1B4L6
• Locus tag: H70737_RS05605
• Protein ID: WP_042124727.1
• Coordinates: 1286204..1286554 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: H70737_RS05600
• Protein ID: WP_154117276.1
• Coordinates: 1285949..1286200 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H70737_RS05585	1281290..1282690	+	1401	WP_042185474.1	helix-turn-helix transcriptional regulator	-
H70737_RS30150	1282813..1282986	+	174	WP_076284026.1	aspartyl-phosphate phosphatase Spo0E family protein	-
H70737_RS05590	1283221..1284306	+	1086	WP_042185477.1	outer membrane lipoprotein carrier protein LolA	-
H70737_RS05595	1284523..1285704	+	1182	WP_042185478.1	alanine racemase	-
H70737_RS05600	1285949..1286200	+	252	WP_154117276.1	ribbon-helix-helix protein, CopG family	Antitoxin
H70737_RS05605	1286204..1286554	+	351	WP_042124727.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
H70737_RS05610	1286711..1287319	+	609	WP_052404177.1	TetR/AcrR family transcriptional regulator	-
H70737_RS05615	1287491..1288690	+	1200	WP_042185479.1	tetracycline resistance MFS efflux pump	-
H70737_RS05620	1288875..1291037	+	2163	WP_197071306.1	RNA-binding transcriptional accessory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-35)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12764.68 Da
• Isoelectric Point: 5.1171

>T48726 WP_042124727.1 NZ_CP009279:1286204-1286554 [Paenibacillus sp. FSL H7-0737]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDDSLQISLGLIDF

Nucleotide

• Length: 351 bp

>T48726 NZ_CP009279:1286204-1286554 [Paenibacillus sp. FSL H7-0737]
TTGATCGTTAAACGTGGCGATGTTTTTTTTGCTGATCTTTCGCCGGTTGTAGGTTCTGAGCAAGGCGGAGTAAGGCCAGT
ACTGGTAATCCAGAATGATATTGGCAATCGCTTTAGCCCGACGGTAATTGTGGCCGCAATCACGGCCCAAATCCAGAAGG
CTAAATTACCTACGCATGTGGAAATTGACGCAGCAGCTCATGGCTTTGACAGAGACTCTGTTATACTGCTGGAGCAGGTT
AGGACGATTGACAAACAACGCTTAACTGACAAGATCACCCACCTTGATGATGAGACTATGAAGAAGGTGGATGATTCGCT
GCAAATCAGCCTCGGACTGATTGATTTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9487.94 Da
• Isoelectric Point: 5.1184

>AT48726 WP_154117276.1 NZ_CP009279:1285949-1286200 [Paenibacillus sp. FSL H7-0737]
MISLPDHLLQEVDGIVQLENSNRSELIRQAMKLYLSERRKRSIRESMQRGYMEMAKINLTMACEAFLAEEDADSTLGRLV
SGV

Nucleotide

• Length: 252 bp

>AT48726 NZ_CP009279:1285949-1286200 [Paenibacillus sp. FSL H7-0737]
ATGATCAGCTTGCCCGATCATCTCTTGCAGGAAGTGGACGGAATTGTTCAATTGGAGAATTCCAACCGGAGTGAATTGAT
TAGGCAGGCCATGAAGCTGTATTTGAGCGAACGGAGGAAACGTTCTATCCGGGAGTCCATGCAGCGCGGCTACATGGAAA
TGGCTAAGATCAACTTGACCATGGCATGCGAGGCGTTCCTCGCGGAGGAAGATGCAGACAGCACTCTTGGCCGCTTAGTA
AGCGGGGTGTAG

Structures

Toxin

• AlphaFold DB: A0A0W1B4L6