Detailed information of TA system TA048666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 253499..253965
• Replicon: plasmid pOCN014
• Accession: NZ_CP009266
• Organism: Vibrio coralliilyticus strain OCN014

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JV59_RS25675
• Protein ID: WP_052131820.1
• Coordinates: 253499..253726 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JV59_RS25680
• Protein ID: WP_040122584.1
• Coordinates: 253723..253965 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JV59_RS25665	249039..251867	+	2829	WP_040122582.1	hypothetical protein	-
JV59_RS25670	252250..252741	-	492	WP_052131832.1	hypothetical protein	-
JV59_RS27120	252840..252989	-	150	WP_158502618.1	hypothetical protein	-
JV59_RS25675	253499..253726	-	228	WP_052131820.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JV59_RS25680	253723..253965	-	243	WP_040122584.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JV59_RS25685	254296..254886	+	591	WP_040122585.1	Crp/Fnr family transcriptional regulator	-
JV59_RS25690	254948..255394	+	447	WP_040122586.1	isoprenylcysteine carboxylmethyltransferase family protein	-
JV59_RS25695	255516..255743	+	228	Protein_240	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
JV59_RS25700	256144..256623	-	480	WP_040122588.1	hypothetical protein	-
JV59_RS25705	257405..257740	+	336	WP_040122589.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..380781	380781

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-73)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-76)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8804.36 Da
• Isoelectric Point: 10.3865

>T48666 WP_052131820.1 NZ_CP009266:c253726-253499 [Vibrio coralliilyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLAGADNMYQIKLRQSGYRLVYKVEDDVIIVTF

Nucleotide

• Length: 228 bp

>T48666 NZ_CP009266:c253726-253499 [Vibrio coralliilyticus]
TTGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAGAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTGCTGGAGCTGACAACATGTATCAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTTATCATTGTCACCTTCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8861.16 Da
• Isoelectric Point: 4.0206

>AT48666 WP_040122584.1 NZ_CP009266:c253965-253723 [Vibrio coralliilyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKEREPEESISVNID

Nucleotide

• Length: 243 bp

>AT48666 NZ_CP009266:c253965-253723 [Vibrio coralliilyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCGATGAAAGTTGCAACTAGTGC
TTACGGTGAACCTGTTGCTGTCTTAAACCGCAATGAACCTGCATTTTATTGCGTACCAGCCGAAGCGTACGAGATGATGA
TGGATAGGCTCGAAGATCTTGAATTGCTCGCTATCGCTAAAGAGCGTGAACCCGAAGAGAGCATTTCGGTCAATATTGAT
TGA