Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1821036..1821585 Replicon chromosome
Accession NZ_CP009261
Organism Vibrio vulnificus strain 93U204

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag VV93_RS08495 Protein ID WP_039553850.1
Coordinates 1821286..1821585 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag VV93_RS08490 Protein ID WP_039553847.1
Coordinates 1821036..1821278 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV93_RS08475 1816853..1817512 - 660 WP_039553841.1 hypothetical protein -
VV93_RS23435 1817513..1817718 - 206 Protein_1649 DUF3265 domain-containing protein -
VV93_RS08480 1817702..1818235 - 534 WP_181392248.1 (d)CMP kinase -
VV93_RS23440 1818222..1818416 - 195 WP_080726356.1 DUF3265 domain-containing protein -
VV93_RS23445 1818720..1818884 - 165 WP_181392249.1 DUF3265 domain-containing protein -
VV93_RS23450 1819190..1819318 - 129 WP_080726407.1 DUF3265 domain-containing protein -
VV93_RS08485 1819787..1820329 - 543 WP_039553845.1 hypothetical protein -
VV93_RS23455 1820814..1820960 - 147 Protein_1655 DUF3265 domain-containing protein -
VV93_RS08490 1821036..1821278 + 243 WP_039553847.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VV93_RS08495 1821286..1821585 + 300 WP_039553850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV93_RS23460 1821631..1821819 - 189 WP_080726358.1 DUF3265 domain-containing protein -
VV93_RS08500 1821850..1822818 + 969 WP_080726343.1 IS30-like element ISVa6 family transposase -
VV93_RS08505 1822853..1823173 - 321 WP_039553852.1 DUF4144 domain-containing protein -
VV93_RS24400 1823311..1823682 - 372 WP_162473092.1 hypothetical protein -
VV93_RS08515 1823791..1824225 - 435 WP_039553855.1 GNAT family N-acetyltransferase -
VV93_RS23465 1824240..1824368 - 129 WP_080726408.1 DUF3265 domain-containing protein -
VV93_RS08520 1824378..1824800 - 423 WP_039553857.1 VOC family protein -
VV93_RS23470 1825301..1825459 - 159 WP_200877305.1 DUF3265 domain-containing protein -
VV93_RS08525 1825525..1826493 + 969 WP_080726343.1 IS30-like element ISVa6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1785871..1855409 69538
- flank IS/Tn - - 1815851..1816819 968
- inside Integron - - 1790432..1855409 64977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11416.02 Da        Isoelectric Point: 9.6265

>T48661 WP_039553850.1 NZ_CP009261:1821286-1821585 [Vibrio vulnificus]
MQKNKYKLSNLAQSHLRKAKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T48661 NZ_CP009261:1821286-1821585 [Vibrio vulnificus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGCAAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTACAAAGACACTCTGCTATCAGGGTTTCAAATGCTAGCTGATAACCCTGGGTTAGGAA
GAAGCTGTGACGAGATATACCCAAATGGCTTTTACTTCCCGATTGGAAAACACACCGCTTATTTCACTAAAGAAGATGGC
TTTATCTTAGTCGTAGCTGTCTTAGGTCAGTCACAGCTCCCACAGAATCATCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9031.26 Da        Isoelectric Point: 5.6926

>AT48661 WP_039553847.1 NZ_CP009261:1821036-1821278 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNAIDGESFLNSL

Download         Length: 243 bp

>AT48661 NZ_CP009261:1821036-1821278 [Vibrio vulnificus]
ATGCATACATTAACAGCGAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAGCCGGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGTTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACGCCATTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References