Detailed information of TA system TA048660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1807484..1807982
• Replicon: chromosome
• Accession: NZ_CP009261
• Organism: Vibrio vulnificus strain 93U204

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: VV93_RS08420
• Protein ID: WP_039553822.1
• Coordinates: 1807716..1807982 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: VV93_RS08415
• Protein ID: WP_039553819.1
• Coordinates: 1807484..1807729 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VV93_RS23350	1803190..1803336	-	147	Protein_1617	DUF3265 domain-containing protein	-
VV93_RS08385	1803333..1803632	-	300	WP_039445221.1	hypothetical protein	-
VV93_RS23355	1803688..1803846	-	159	WP_162473091.1	DUF3265 domain-containing protein	-
VV93_RS08390	1803877..1804845	+	969	WP_080726343.1	IS30-like element ISVa6 family transposase	-
VV93_RS08395	1804890..1805465	-	576	WP_080726347.1	DUF3265 domain-containing protein	-
VV93_RS08400	1805514..1805747	-	234	WP_039553812.1	hypothetical protein	-
VV93_RS23360	1805785..1805907	-	123	Protein_1623	DUF3265 domain-containing protein	-
VV93_RS08405	1805912..1806376	-	465	WP_039553816.1	ASCH domain-containing protein	-
VV93_RS23365	1806369..1806527	-	159	WP_080726348.1	DUF3265 domain-containing protein	-
VV93_RS23375	1806870..1806998	-	129	WP_080726404.1	DUF3265 domain-containing protein	-
VV93_RS08410	1807008..1807229	-	222	WP_000076907.1	VF530 family protein	-
VV93_RS08415	1807484..1807729	-	246	WP_039553819.1	hypothetical protein	Antitoxin
VV93_RS08420	1807716..1807982	-	267	WP_039553822.1	BrnT family toxin	Toxin
VV93_RS23385	1808038..1808190	-	153	WP_080726350.1	DUF3265 domain-containing protein	-
VV93_RS08425	1808256..1809224	+	969	WP_080726343.1	IS30-like element ISVa6 family transposase	-
VV93_RS08430	1809258..1809662	-	405	WP_051934097.1	hypothetical protein	-
VV93_RS23390	1809696..1809812	-	117	WP_080726405.1	DUF3265 domain-containing protein	-
VV93_RS08435	1809815..1810018	-	204	WP_039553825.1	hypothetical protein	-
VV93_RS23395	1810044..1810193	-	150	WP_080726351.1	DUF3265 domain-containing protein	-
VV93_RS23400	1810536..1810664	-	129	WP_080726406.1	DUF3265 domain-containing protein	-
VV93_RS23410	1811024..1811158	-	135	WP_080726352.1	DUF3265 domain-containing protein	-
VV93_RS08440	1811131..1811694	-	564	WP_039553828.1	hypothetical protein	-
VV93_RS23415	1811710..1811835	-	126	WP_080726353.1	DUF3265 domain-containing protein	-
VV93_RS08445	1811842..1812249	-	408	WP_010644697.1	NUDIX hydrolase	-
VV93_RS23420	1812269..1812391	-	123	WP_072610512.1	DUF3265 domain-containing protein	-
VV93_RS08450	1812401..1812907	-	507	WP_011150451.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1785871..1855409	69538
	-	inside	IScluster/Tn	-	-	1803877..1809224	5347
	-	inside	Integron	-	-	1790432..1855409	64977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10122.37 Da
• Isoelectric Point: 7.3171

>T48660 WP_039553822.1 NZ_CP009261:c1807982-1807716 [Vibrio vulnificus]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKT
EVSLYESA

Nucleotide

• Length: 267 bp

>T48660 NZ_CP009261:c1807982-1807716 [Vibrio vulnificus]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAACG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9494.77 Da
• Isoelectric Point: 6.4832

>AT48660 WP_039553819.1 NZ_CP009261:c1807729-1807484 [Vibrio vulnificus]
MKAHEFDSKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT48660 NZ_CP009261:c1807729-1807484 [Vibrio vulnificus]
ATGAAAGCGCATGAATTTGATTCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA