Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1796830..1797358 Replicon chromosome
Accession NZ_CP009261
Organism Vibrio vulnificus strain 93U204

Toxin (Protein)


Gene name relE Uniprot ID A0A7X8YM79
Locus tag VV93_RS08340 Protein ID WP_020840746.1
Coordinates 1797068..1797358 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag VV93_RS08335 Protein ID WP_005377003.1
Coordinates 1796830..1797078 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV93_RS08310 1792484..1793245 - 762 WP_039553781.1 hypothetical protein -
VV93_RS23315 1793274..1793417 - 144 WP_080726342.1 DUF3265 domain-containing protein -
VV93_RS23320 1793760..1793856 - 97 Protein_1598 DUF3265 domain-containing protein -
VV93_RS08315 1793885..1794316 - 432 WP_039553784.1 hypothetical protein -
VV93_RS23325 1794334..1794468 - 135 WP_200877308.1 DUF3265 domain-containing protein -
VV93_RS08320 1794479..1794748 - 270 WP_005492798.1 Txe/YoeB family addiction module toxin -
VV93_RS08325 1794741..1794995 - 255 WP_005492799.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
VV93_RS08330 1795308..1796276 + 969 WP_080726343.1 IS30-like element ISVa6 family transposase -
VV93_RS24055 1796687..1796755 - 69 WP_200877309.1 DUF3265 domain-containing protein -
VV93_RS08335 1796830..1797078 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VV93_RS08340 1797068..1797358 + 291 WP_020840746.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV93_RS08345 1797509..1797958 - 450 WP_039553792.1 hypothetical protein -
VV93_RS24460 1797980..1798147 - 168 Protein_1608 DUF3265 domain-containing protein -
VV93_RS08350 1798113..1798634 - 522 WP_039553794.1 GNAT family N-acetyltransferase -
VV93_RS08355 1798771..1799244 - 474 WP_039553797.1 HAD family hydrolase -
VV93_RS08360 1799936..1800343 - 408 WP_039553800.1 GFA family protein -
VV93_RS08365 1800497..1800952 - 456 WP_173652411.1 GNAT family N-acetyltransferase -
VV93_RS23335 1800963..1801091 - 129 WP_080726402.1 DUF3265 domain-containing protein -
VV93_RS08370 1801088..1801588 - 501 WP_039553804.1 DUF2569 domain-containing protein -
VV93_RS23340 1802158..1802259 - 102 WP_080726403.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1785871..1855409 69538
- inside IScluster/Tn - - 1791490..1796276 4786
- inside Integron - - 1790432..1855409 64977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11288.28 Da        Isoelectric Point: 10.5932

>T48659 WP_020840746.1 NZ_CP009261:1797068-1797358 [Vibrio vulnificus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERNDVYRKAMKRLDD

Download         Length: 291 bp

>T48659 NZ_CP009261:1797068-1797358 [Vibrio vulnificus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTGATAGAACGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCTGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTAGGAAAA
CGCGAACGTAACGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT48659 WP_005377003.1 NZ_CP009261:1796830-1797078 [Vibrio vulnificus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT48659 NZ_CP009261:1796830-1797078 [Vibrio vulnificus]
ATGACCACTAGGATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACCGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAAAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8YM79

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References