Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 796645..798473 Replicon chromosome
Accession NZ_CP009261
Organism Vibrio vulnificus strain 93U204

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag VV93_RS03745 Protein ID WP_039552891.1
Coordinates 797112..798473 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag VV93_RS03740 Protein ID WP_029786578.1
Coordinates 796645..797127 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV93_RS03720 792662..793216 + 555 WP_011078504.1 hypothetical protein -
VV93_RS03725 793218..793973 + 756 WP_039552881.1 NRDE family protein -
VV93_RS03730 793988..794425 + 438 WP_039552884.1 YHS domain-containing protein -
VV93_RS03735 794468..796210 + 1743 WP_039552887.1 lysophospholipid acyltransferase family protein -
VV93_RS03740 796645..797127 - 483 WP_029786578.1 helix-turn-helix domain-containing protein Antitoxin
VV93_RS03745 797112..798473 - 1362 WP_039552891.1 type II toxin-antitoxin system HipA family toxin Toxin
VV93_RS03750 799050..800303 - 1254 WP_039552893.1 hypothetical protein -
VV93_RS03755 800894..801529 + 636 WP_039552896.1 inovirus Gp2 family protein -
VV93_RS03760 801594..802346 + 753 WP_039552898.1 inovirus Gp2 family protein -
VV93_RS03765 802336..802935 + 600 WP_039552901.1 inovirus Gp2 family protein -
VV93_RS03770 803000..803200 + 201 WP_001211744.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 796645..821747 25102


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51460.24 Da        Isoelectric Point: 4.8137

>T48657 WP_039552891.1 NZ_CP009261:c798473-797112 [Vibrio vulnificus]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFNDMGKPGWLKFLDDIM
PSGASRRYWVRYLDIEDLSSDEQDYVLLKFGTMSPVGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYALQRGAAA
GGATGAGGEAPKLILRCGLDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFIGIADTLSDLV
PKEVLLQELEITASKCIDLKQRLALRGIPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T48657 NZ_CP009261:c798473-797112 [Vibrio vulnificus]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAAGTGAATGGATAGACATTGGTATCATCTCATTCCCAAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTATCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTAATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGCGGCGCTAGTAGACGGTACTGGGTCAGATATCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTGTTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACTGCAAAGGGGCGCAGCCGCG
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTCTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCAGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTAATGAGCA
GCAAATCGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCATTAGAGGTTGGCGGAACTTACGACTTCATCGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAGGTGTTATTACAAGAGCTAGAGATTACTGCAAGTAAATGCATTGACTTAAAGCAGAGACTAGCATTACGAGG
AATACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17535.05 Da        Isoelectric Point: 10.8446

>AT48657 WP_029786578.1 NZ_CP009261:c797127-796645 [Vibrio vulnificus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT48657 NZ_CP009261:c797127-796645 [Vibrio vulnificus]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AGCCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References