Detailed information of TA system TA048653

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4328302..4328981
• Replicon: chromosome
• Accession: NZ_CP009257
• Organism: Acinetobacter baumannii strain AB30

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: IX87_RS21630
• Protein ID: WP_000838146.1
• Coordinates: 4328799..4328981 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: IX87_RS21625
• Protein ID: WP_000966688.1
• Coordinates: 4328302..4328706 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IX87_RS21620	4327679..4328203	-	525	WP_031977118.1	DUF4468 domain-containing protein	-
IX87_RS21625	4328302..4328706	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IX87_RS21630	4328799..4328981	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
IX87_RS21635	4329307..4329822	-	516	WP_042791412.1	hypothetical protein	-
IX87_RS21640	4329892..4330809	-	918	WP_042791413.1	hypothetical protein	-
IX87_RS21645	4330905..4332047	-	1143	WP_042791473.1	hypothetical protein	-
IX87_RS21650	4332047..4332400	-	354	WP_031958596.1	hypothetical protein	-
IX87_RS21655	4332469..4332912	-	444	WP_049867451.1	hypothetical protein	-
IX87_RS21660	4332869..4333237	-	369	WP_042791648.1	HK97 gp10 family phage protein	-
IX87_RS21665	4333209..4333613	-	405	WP_042791650.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T48653 WP_000838146.1 NZ_CP009257:c4328981-4328799 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T48653 NZ_CP009257:c4328981-4328799 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT48653 WP_000966688.1 NZ_CP009257:c4328706-4328302 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT48653 NZ_CP009257:c4328706-4328302 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6