Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2322731..2323384 Replicon chromosome
Accession NZ_CP009257
Organism Acinetobacter baumannii strain AB30

Toxin (Protein)


Gene name cptA Uniprot ID A0A427QZH0
Locus tag IX87_RS11715 Protein ID WP_000931891.1
Coordinates 2322731..2323120 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag IX87_RS11720 Protein ID WP_001288210.1
Coordinates 2323127..2323384 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IX87_RS11700 2317849..2320044 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
IX87_RS11705 2320232..2320798 - 567 WP_000651536.1 rhombosortase -
IX87_RS11710 2320876..2321961 - 1086 WP_000049104.1 hypothetical protein -
IX87_RS11715 2322731..2323120 - 390 WP_000931891.1 hypothetical protein Toxin
IX87_RS11720 2323127..2323384 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
IX87_RS11725 2323572..2324744 + 1173 WP_001190558.1 acyl-CoA dehydrogenase family protein -
IX87_RS11730 2324794..2326284 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
IX87_RS11735 2326466..2326843 - 378 WP_001216380.1 50S ribosomal protein L17 -
IX87_RS11740 2326862..2327869 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T48652 WP_000931891.1 NZ_CP009257:c2323120-2322731 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T48652 NZ_CP009257:c2323120-2322731 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCGCAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT48652 WP_001288210.1 NZ_CP009257:c2323384-2323127 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT48652 NZ_CP009257:c2323384-2323127 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427QZH0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References