Detailed information of TA system TA048651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1560840..1561519
• Replicon: chromosome
• Accession: NZ_CP009257
• Organism: Acinetobacter baumannii strain AB30

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: IX87_RS08030
• Protein ID: WP_000838146.1
• Coordinates: 1561337..1561519 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: IX87_RS08025
• Protein ID: WP_000966688.1
• Coordinates: 1560840..1561244 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IX87_RS07990	1556723..1557070	-	348	WP_000130334.1	hypothetical protein	-
IX87_RS07995	1557401..1558402	-	1002	WP_000835375.1	KilA-N domain-containing protein	-
IX87_RS08000	1558399..1558569	-	171	WP_000538615.1	Arc family DNA-binding protein	-
IX87_RS08005	1558685..1558996	+	312	WP_000041780.1	Arc family DNA-binding protein	-
IX87_RS08010	1559010..1559753	-	744	WP_000599538.1	hypothetical protein	-
IX87_RS08015	1559815..1560198	-	384	WP_000725052.1	hypothetical protein	-
IX87_RS08020	1560231..1560555	-	325	Protein_1568	DUF4236 domain-containing protein	-
IX87_RS22170	1560564..1560740	-	177	WP_002012864.1	hypothetical protein	-
IX87_RS08025	1560840..1561244	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IX87_RS08030	1561337..1561519	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
IX87_RS08035	1561845..1562360	-	516	WP_042791412.1	hypothetical protein	-
IX87_RS08040	1562430..1563347	-	918	WP_042791413.1	hypothetical protein	-
IX87_RS08045	1563443..1564585	-	1143	WP_042791473.1	hypothetical protein	-
IX87_RS08050	1564585..1564938	-	354	WP_042791474.1	hypothetical protein	-
IX87_RS08055	1564997..1565215	-	219	WP_042791475.1	hypothetical protein	-
IX87_RS08060	1565217..1565615	-	399	WP_042791476.1	hypothetical protein	-
IX87_RS08065	1565617..1565985	-	369	WP_005135680.1	hypothetical protein	-
IX87_RS08070	1565957..1566367	-	411	WP_042791477.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1544269..1593518	49249

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T48651 WP_000838146.1 NZ_CP009257:c1561519-1561337 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T48651 NZ_CP009257:c1561519-1561337 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT48651 WP_000966688.1 NZ_CP009257:c1561244-1560840 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT48651 NZ_CP009257:c1561244-1560840 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6