Detailed information of TA system TA048650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 925346..926025
• Replicon: chromosome
• Accession: NZ_CP009257
• Organism: Acinetobacter baumannii strain AB30

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: IX87_RS04720
• Protein ID: WP_000838146.1
• Coordinates: 925843..926025 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: IX87_RS04715
• Protein ID: WP_000966688.1
• Coordinates: 925346..925750 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IX87_RS04710	924723..925247	-	525	WP_031977118.1	DUF4468 domain-containing protein	-
IX87_RS04715	925346..925750	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IX87_RS04720	925843..926025	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
IX87_RS04725	926351..926866	-	516	WP_038347600.1	hypothetical protein	-
IX87_RS04730	926938..927855	-	918	WP_000094260.1	hypothetical protein	-
IX87_RS04735	927952..929100	-	1149	WP_042791385.1	hypothetical protein	-
IX87_RS04740	929100..929453	-	354	WP_042791386.1	hypothetical protein	-
IX87_RS04745	929522..929965	-	444	WP_016654267.1	hypothetical protein	-
IX87_RS04750	929922..930290	-	369	WP_042791387.1	hypothetical protein	-
IX87_RS04755	930262..930666	-	405	WP_042791388.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	909043..957987	48944

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T48650 WP_000838146.1 NZ_CP009257:c926025-925843 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T48650 NZ_CP009257:c926025-925843 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT48650 WP_000966688.1 NZ_CP009257:c925750-925346 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT48650 NZ_CP009257:c925750-925346 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6