Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2473510..2474131 Replicon chromosome
Accession NZ_CP009249
Organism Corynebacterium phocae strain M408/89/1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CPHO_RS11345 Protein ID WP_075735863.1
Coordinates 2473814..2474131 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CPHO_RS11340 Protein ID WP_075735861.1
Coordinates 2473510..2473812 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPHO_RS11315 2469207..2470457 + 1251 WP_075735855.1 YibE/F family protein -
CPHO_RS11320 2470450..2470920 + 471 WP_075735857.1 META domain-containing protein -
CPHO_RS11325 2470917..2472239 - 1323 WP_075735859.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
CPHO_RS11330 2472339..2472902 - 564 WP_075736719.1 dCTP deaminase -
CPHO_RS11340 2473510..2473812 - 303 WP_075735861.1 putative addiction module antidote protein Antitoxin
CPHO_RS11345 2473814..2474131 - 318 WP_075735863.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPHO_RS11350 2474305..2475285 - 981 WP_150385795.1 Abi family protein -
CPHO_RS11355 2475642..2478557 + 2916 WP_075735865.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-98)

Antitoxin

Uncharacterized protein HI1420

(9-95)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11884.77 Da        Isoelectric Point: 10.3681

>T48647 WP_075735863.1 NZ_CP009249:c2474131-2473814 [Corynebacterium phocae]
MGYNGVVEIRETDHFSSWLKSLKDMRSKARILYAITKCERASRMVGDIKAVGGVHEIRLHFGPGYRLYYAQHGKTLVWLL
AGGDKSTQSRDIKLAKRLAKEFAEG

Download         Length: 318 bp

>T48647 NZ_CP009249:c2474131-2473814 [Corynebacterium phocae]
ATGGGCTACAATGGTGTCGTGGAAATTCGCGAAACCGATCACTTTTCCTCTTGGCTGAAGAGCCTTAAAGATATGAGGAG
TAAGGCGCGAATCTTGTATGCCATAACGAAGTGTGAAAGAGCATCCCGGATGGTCGGGGACATTAAAGCAGTTGGTGGTG
TTCATGAGATTCGACTCCATTTCGGTCCCGGATACCGCCTCTACTACGCGCAGCATGGAAAGACCTTGGTGTGGCTGCTT
GCAGGTGGAGACAAGTCCACACAGTCAAGAGATATTAAACTTGCCAAACGGTTAGCGAAGGAATTTGCGGAGGGATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10958.48 Da        Isoelectric Point: 6.3530

>AT48647 WP_075735861.1 NZ_CP009249:c2473812-2473510 [Corynebacterium phocae]
MNTKVATRTRRFDASEYLDNAETVREYLAAALEDGDPRDIQLVLRDIAKAQGMSALATKSGLNRESLYKSLSAEGNPSFA
TILRVMEALGLKLTLAPEAR

Download         Length: 303 bp

>AT48647 NZ_CP009249:c2473812-2473510 [Corynebacterium phocae]
ATGAATACGAAGGTCGCTACTAGGACGCGGAGATTTGATGCCAGTGAGTATCTGGATAATGCCGAAACGGTGCGCGAATA
CCTCGCCGCTGCTCTAGAGGACGGAGATCCGCGAGATATCCAACTAGTCCTACGGGATATTGCCAAGGCCCAAGGAATGA
GCGCTCTAGCCACGAAATCCGGCCTCAACCGCGAGTCGCTGTACAAGTCCCTGTCGGCCGAAGGGAATCCCTCTTTCGCA
ACCATTTTGCGAGTTATGGAAGCATTGGGGCTCAAGCTGACCCTGGCGCCAGAAGCTCGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References