Detailed information of TA system TA048647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2473510..2474131
• Replicon: chromosome
• Accession: NZ_CP009249
• Organism: Corynebacterium phocae strain M408/89/1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: CPHO_RS11345
• Protein ID: WP_075735863.1
• Coordinates: 2473814..2474131 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CPHO_RS11340
• Protein ID: WP_075735861.1
• Coordinates: 2473510..2473812 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPHO_RS11315	2469207..2470457	+	1251	WP_075735855.1	YibE/F family protein	-
CPHO_RS11320	2470450..2470920	+	471	WP_075735857.1	META domain-containing protein	-
CPHO_RS11325	2470917..2472239	-	1323	WP_075735859.1	UDP-glucose/GDP-mannose dehydrogenase family protein	-
CPHO_RS11330	2472339..2472902	-	564	WP_075736719.1	dCTP deaminase	-
CPHO_RS11340	2473510..2473812	-	303	WP_075735861.1	putative addiction module antidote protein	Antitoxin
CPHO_RS11345	2473814..2474131	-	318	WP_075735863.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPHO_RS11350	2474305..2475285	-	981	WP_150385795.1	Abi family protein	-
CPHO_RS11355	2475642..2478557	+	2916	WP_075735865.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-98)

Antitoxin

• Uncharacterized protein HI1420 (9-95)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11884.77 Da
• Isoelectric Point: 10.3681

>T48647 WP_075735863.1 NZ_CP009249:c2474131-2473814 [Corynebacterium phocae]
MGYNGVVEIRETDHFSSWLKSLKDMRSKARILYAITKCERASRMVGDIKAVGGVHEIRLHFGPGYRLYYAQHGKTLVWLL
AGGDKSTQSRDIKLAKRLAKEFAEG

Nucleotide

• Length: 318 bp

>T48647 NZ_CP009249:c2474131-2473814 [Corynebacterium phocae]
ATGGGCTACAATGGTGTCGTGGAAATTCGCGAAACCGATCACTTTTCCTCTTGGCTGAAGAGCCTTAAAGATATGAGGAG
TAAGGCGCGAATCTTGTATGCCATAACGAAGTGTGAAAGAGCATCCCGGATGGTCGGGGACATTAAAGCAGTTGGTGGTG
TTCATGAGATTCGACTCCATTTCGGTCCCGGATACCGCCTCTACTACGCGCAGCATGGAAAGACCTTGGTGTGGCTGCTT
GCAGGTGGAGACAAGTCCACACAGTCAAGAGATATTAAACTTGCCAAACGGTTAGCGAAGGAATTTGCGGAGGGATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10958.48 Da
• Isoelectric Point: 6.3530

>AT48647 WP_075735861.1 NZ_CP009249:c2473812-2473510 [Corynebacterium phocae]
MNTKVATRTRRFDASEYLDNAETVREYLAAALEDGDPRDIQLVLRDIAKAQGMSALATKSGLNRESLYKSLSAEGNPSFA
TILRVMEALGLKLTLAPEAR

Nucleotide

• Length: 303 bp

>AT48647 NZ_CP009249:c2473812-2473510 [Corynebacterium phocae]
ATGAATACGAAGGTCGCTACTAGGACGCGGAGATTTGATGCCAGTGAGTATCTGGATAATGCCGAAACGGTGCGCGAATA
CCTCGCCGCTGCTCTAGAGGACGGAGATCCGCGAGATATCCAACTAGTCCTACGGGATATTGCCAAGGCCCAAGGAATGA
GCGCTCTAGCCACGAAATCCGGCCTCAACCGCGAGTCGCTGTACAAGTCCCTGTCGGCCGAAGGGAATCCCTCTTTCGCA
ACCATTTTGCGAGTTATGGAAGCATTGGGGCTCAAGCTGACCCTGGCGCCAGAAGCTCGCTAG