48633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2887294..2888008 Replicon chromosome
Accession NZ_CP009243
Organism Mycobacterium tuberculosis variant bovis BCG strain Russia 368

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag BCGR_RS13510 Protein ID WP_003413460.1
Coordinates 2887568..2888008 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag BCGR_RS13505 Protein ID WP_003413456.1
Coordinates 2887294..2887581 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGR_RS13470 2882726..2882971 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BCGR_RS13475 2882968..2883372 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
BCGR_RS13480 2883589..2884209 + 621 WP_003413441.1 DUF4178 domain-containing protein -
BCGR_RS13485 2884220..2884714 + 495 WP_003413444.1 DUF2617 family protein -
BCGR_RS13490 2884711..2885142 + 432 WP_003413445.1 DUF4247 domain-containing protein -
BCGR_RS13495 2885167..2885615 + 449 Protein_2627 DUF350 domain-containing protein -
BCGR_RS13500 2885612..2887183 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
BCGR_RS13505 2887294..2887581 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
BCGR_RS13510 2887568..2888008 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGR_RS13515 2888029..2888784 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
BCGR_RS13520 2888917..2889513 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
BCGR_RS13525 2889521..2890366 - 846 WP_010950749.1 acyl-CoA thioesterase II -
BCGR_RS13530 2890395..2891294 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
BCGR_RS13535 2891422..2892096 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T48633 WP_003413460.1 NZ_CP009243:2887568-2888008 [Mycobacterium tuberculosis variant bovis BCG]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T48633 NZ_CP009243:2887568-2888008 [Mycobacterium tuberculosis variant bovis BCG]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT48633 WP_003413456.1 NZ_CP009243:2887294-2887581 [Mycobacterium tuberculosis variant bovis BCG]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT48633 NZ_CP009243:2887294-2887581 [Mycobacterium tuberculosis variant bovis BCG]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References