48628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2764657..2765309 Replicon chromosome
Accession NZ_CP009243
Organism Mycobacterium tuberculosis variant bovis BCG strain Russia 368

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag BCGR_RS12935 Protein ID WP_003412752.1
Coordinates 2764884..2765309 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag BCGR_RS12930 Protein ID WP_003412749.1
Coordinates 2764657..2764878 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGR_RS12915 2762897..2763103 - 207 WP_003899347.1 hypothetical protein -
BCGR_RS12920 2763239..2763862 + 624 WP_003900858.1 TIGR00725 family protein -
BCGR_RS12925 2763852..2764604 + 753 WP_003901416.1 hypothetical protein -
BCGR_RS12930 2764657..2764878 + 222 WP_003412749.1 antitoxin Antitoxin
BCGR_RS12935 2764884..2765309 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGR_RS12940 2765332..2766513 - 1182 WP_010950729.1 2-oxo acid dehydrogenase subunit E2 -
BCGR_RS12945 2766510..2767556 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
BCGR_RS12950 2767567..2768670 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
BCGR_RS12955 2768929..2769750 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
BCGR_RS12960 2769747..2770304 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T48628 WP_003412752.1 NZ_CP009243:2764884-2765309 [Mycobacterium tuberculosis variant bovis BCG]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T48628 NZ_CP009243:2764884-2765309 [Mycobacterium tuberculosis variant bovis BCG]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT48628 WP_003412749.1 NZ_CP009243:2764657-2764878 [Mycobacterium tuberculosis variant bovis BCG]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT48628 NZ_CP009243:2764657-2764878 [Mycobacterium tuberculosis variant bovis BCG]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References