Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2187835..2188379 | Replicon | chromosome |
| Accession | NZ_CP009243 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Russia 368 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | BCGR_RS10165 | Protein ID | WP_003409896.1 |
| Coordinates | 2187835..2188131 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | BCGR_RS10170 | Protein ID | WP_003409899.1 |
| Coordinates | 2188128..2188379 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BCGR_RS10110 | 2182868..2183218 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| BCGR_RS10115 | 2183229..2184131 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| BCGR_RS10120 | 2184152..2184343 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| BCGR_RS10125 | 2184344..2184640 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| BCGR_RS10130 | 2184880..2185095 | + | 216 | WP_003409878.1 | antitoxin | - |
| BCGR_RS10135 | 2185092..2185403 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| BCGR_RS22115 | 2185377..2185898 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| BCGR_RS10145 | 2185873..2186250 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| BCGR_RS10150 | 2186292..2186741 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| BCGR_RS10155 | 2186738..2187283 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| BCGR_RS10160 | 2187172..2187786 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| BCGR_RS10165 | 2187835..2188131 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BCGR_RS10170 | 2188128..2188379 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| BCGR_RS10175 | 2188366..2188860 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| BCGR_RS10180 | 2189020..2189427 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| BCGR_RS10185 | 2189431..2189703 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| BCGR_RS10190 | 2189736..2190956 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| BCGR_RS10200 | 2191855..2192160 | + | 306 | Protein_1991 | ABC transporter permease | - |
| BCGR_RS10205 | 2192344..2193192 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T48619 WP_003409896.1 NZ_CP009243:c2188131-2187835 [Mycobacterium tuberculosis variant bovis BCG]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T48619 NZ_CP009243:c2188131-2187835 [Mycobacterium tuberculosis variant bovis BCG]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT48619 WP_003409899.1 NZ_CP009243:c2188379-2188128 [Mycobacterium tuberculosis variant bovis BCG]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT48619 NZ_CP009243:c2188379-2188128 [Mycobacterium tuberculosis variant bovis BCG]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |