48615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1925154..1925767 Replicon chromosome
Accession NZ_CP009243
Organism Mycobacterium tuberculosis variant bovis BCG strain Russia 368

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag BCGR_RS08940 Protein ID WP_003408465.1
Coordinates 1925154..1925543 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag BCGR_RS08945 Protein ID WP_003408469.1
Coordinates 1925540..1925767 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGR_RS08910 1920784..1921698 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
BCGR_RS08915 1921701..1922531 + 831 WP_003408448.1 cyclase family protein -
BCGR_RS08920 1922531..1922881 + 351 WP_003898986.1 cupin domain-containing protein -
BCGR_RS08925 1922934..1923751 + 818 Protein_1740 3-keto-5-aminohexanoate cleavage protein -
BCGR_RS08930 1923765..1924544 + 780 WP_003408460.1 IclR family transcriptional regulator -
BCGR_RS08940 1925154..1925543 - 390 WP_003408465.1 PIN domain-containing protein Toxin
BCGR_RS08945 1925540..1925767 - 228 WP_003408469.1 antitoxin Antitoxin
BCGR_RS08950 1925985..1927469 + 1485 WP_010950580.1 biotin carboxylase -
BCGR_RS08955 1927466..1928713 + 1248 WP_003408476.1 serine hydrolase -
BCGR_RS08960 1928756..1929175 - 420 WP_003408483.1 hypothetical protein -
BCGR_RS08965 1929165..1929875 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T48615 WP_003408465.1 NZ_CP009243:c1925543-1925154 [Mycobacterium tuberculosis variant bovis BCG]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T48615 NZ_CP009243:c1925543-1925154 [Mycobacterium tuberculosis variant bovis BCG]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT48615 WP_003408469.1 NZ_CP009243:c1925767-1925540 [Mycobacterium tuberculosis variant bovis BCG]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT48615 NZ_CP009243:c1925767-1925540 [Mycobacterium tuberculosis variant bovis BCG]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References