48613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1684243..1684859 Replicon chromosome
Accession NZ_CP009243
Organism Mycobacterium tuberculosis variant bovis BCG strain Russia 368

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag BCGR_RS07935 Protein ID WP_003407593.1
Coordinates 1684542..1684859 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U4BU54
Locus tag BCGR_RS07930 Protein ID WP_011799188.1
Coordinates 1684243..1684545 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGR_RS07920 1680129..1681976 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
BCGR_RS07925 1681977..1684229 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
BCGR_RS07930 1684243..1684545 + 303 WP_011799188.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
BCGR_RS07935 1684542..1684859 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
BCGR_RS07940 1684856..1685860 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
BCGR_RS07945 1685913..1687202 + 1290 WP_003407599.1 serine hydrolase -
BCGR_RS07950 1687275..1688048 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
BCGR_RS07955 1688106..1688297 - 192 WP_003407609.1 dodecin family protein -
BCGR_RS22105 1688328..1688552 - 225 WP_160522526.1 NUDIX domain-containing protein -
BCGR_RS07965 1688822..1689850 + 1029 WP_011799189.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T48613 WP_003407593.1 NZ_CP009243:1684542-1684859 [Mycobacterium tuberculosis variant bovis BCG]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T48613 NZ_CP009243:1684542-1684859 [Mycobacterium tuberculosis variant bovis BCG]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11199.50 Da        Isoelectric Point: 9.5564

>AT48613 WP_011799188.1 NZ_CP009243:1684243-1684545 [Mycobacterium tuberculosis variant bovis BCG]
VPFLVALSGIILGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT48613 NZ_CP009243:1684243-1684545 [Mycobacterium tuberculosis variant bovis BCG]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTTGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BU54

References