48612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1571792..1572447 Replicon chromosome
Accession NZ_CP009243
Organism Mycobacterium tuberculosis variant bovis BCG strain Russia 368

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag BCGR_RS07415 Protein ID WP_003407268.1
Coordinates 1571792..1572193 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag BCGR_RS07420 Protein ID WP_003407272.1
Coordinates 1572190..1572447 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGR_RS07400 1567636..1569021 - 1386 WP_003407260.1 cytochrome P450 -
BCGR_RS07405 1569099..1570133 + 1035 WP_003407264.1 AraC family transcriptional regulator -
BCGR_RS07410 1570179..1571537 - 1359 WP_010950541.1 PE family protein -
BCGR_RS07415 1571792..1572193 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
BCGR_RS07420 1572190..1572447 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
BCGR_RS07425 1572530..1573489 - 960 WP_011799179.1 alpha/beta hydrolase -
BCGR_RS07430 1573514..1574476 - 963 WP_003407279.1 alpha/beta hydrolase -
BCGR_RS07435 1574475..1575212 + 738 WP_031647000.1 lysoplasmalogenase -
BCGR_RS07440 1575293..1577260 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T48612 WP_003407268.1 NZ_CP009243:c1572193-1571792 [Mycobacterium tuberculosis variant bovis BCG]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T48612 NZ_CP009243:c1572193-1571792 [Mycobacterium tuberculosis variant bovis BCG]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT48612 WP_003407272.1 NZ_CP009243:c1572447-1572190 [Mycobacterium tuberculosis variant bovis BCG]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT48612 NZ_CP009243:c1572447-1572190 [Mycobacterium tuberculosis variant bovis BCG]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References