48599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754751..755384 Replicon chromosome
Accession NZ_CP009243
Organism Mycobacterium tuberculosis variant bovis BCG strain Russia 368

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag BCGR_RS03455 Protein ID WP_003403365.1
Coordinates 754751..755134 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag BCGR_RS03460 Protein ID WP_003403368.1
Coordinates 755229..755384 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGR_RS03430 750043..750579 + 537 WP_003403341.1 50S ribosomal protein L10 -
BCGR_RS03435 750616..751008 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
BCGR_RS03440 751001..751696 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
BCGR_RS03445 751767..753272 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
BCGR_RS03450 753353..754363 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
BCGR_RS03455 754751..755134 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
BCGR_RS03460 755229..755384 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BCGR_RS03465 755460..756176 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
BCGR_RS03470 756452..756760 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
BCGR_RS03475 756747..756992 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
BCGR_RS03480 757102..757539 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
BCGR_RS03485 757536..757790 - 255 WP_003911263.1 antitoxin VapB7 -
BCGR_RS03490 757904..760267 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T48599 WP_003403365.1 NZ_CP009243:c755134-754751 [Mycobacterium tuberculosis variant bovis BCG]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T48599 NZ_CP009243:c755134-754751 [Mycobacterium tuberculosis variant bovis BCG]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT48599 WP_003403368.1 NZ_CP009243:c755384-755229 [Mycobacterium tuberculosis variant bovis BCG]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT48599 NZ_CP009243:c755384-755229 [Mycobacterium tuberculosis variant bovis BCG]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References