Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1376550..1377155 Replicon chromosome
Accession NZ_CP009241
Organism Paenibacillus sp. FSL H7-0357

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H70357_RS06070 Protein ID WP_038586937.1
Coordinates 1376805..1377155 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H70357_RS06065 Protein ID WP_197073704.1
Coordinates 1376550..1376801 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H70357_RS06045 1372042..1372695 + 654 WP_038598751.1 M48 family metallopeptidase -
H70357_RS06050 1372744..1373619 - 876 WP_038598754.1 GNAT family N-acetyltransferase -
H70357_RS06055 1373812..1374897 + 1086 WP_038586931.1 outer membrane lipoprotein-sorting protein -
H70357_RS06060 1375126..1376307 + 1182 WP_038586934.1 alanine racemase -
H70357_RS06065 1376550..1376801 + 252 WP_197073704.1 ribbon-helix-helix protein, CopG family Antitoxin
H70357_RS06070 1376805..1377155 + 351 WP_038586937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H70357_RS06075 1377322..1377930 + 609 WP_197073656.1 TetR/AcrR family transcriptional regulator -
H70357_RS06080 1378209..1379417 + 1209 WP_038586944.1 tetracycline resistance MFS efflux pump -
H70357_RS06085 1379603..1381801 + 2199 WP_179091766.1 RNA-binding transcriptional accessory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12764.68 Da        Isoelectric Point: 5.1057

>T48585 WP_038586937.1 NZ_CP009241:1376805-1377155 [Paenibacillus sp. FSL H7-0357]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDDTMKKVDDSLQISLGLIDF

Download         Length: 351 bp

>T48585 NZ_CP009241:1376805-1377155 [Paenibacillus sp. FSL H7-0357]
TTGATCGTTAAACGCGGCGACGTTTTTTTTGCCGACCTTTCGCCTGTTGTAGGTTCAGAACAAGGCGGAGTACGGCCGGT
ACTGATTATTCAGAACGATATTGGCAACCGTTTCAGCCCGACGGTGATTGTGGCAGCCATCACTGCCCAGATCCAGAAGG
CCAAACTGCCGACGCACGTGGAAATTGATGCGGCAGCCCACGGCTTTGACCGGGATTCCGTTATTCTCCTCGAGCAGGTT
CGGACAATTGACAAGCAACGCTTGACCGATAAGATCACCCACCTTGACGATGATACAATGAAGAAAGTGGATGATTCGCT
GCAAATCAGTCTGGGCCTGATCGATTTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9485.97 Da        Isoelectric Point: 5.1184

>AT48585 WP_197073704.1 NZ_CP009241:1376550-1376801 [Paenibacillus sp. FSL H7-0357]
MISLPDHLLQEVDGIAQLENSNRSELIRQAMKLYLSERRKRIIRESMQRGYMEMAKINLTMACEAFLAEEDADSTLGRLV
SGV

Download         Length: 252 bp

>AT48585 NZ_CP009241:1376550-1376801 [Paenibacillus sp. FSL H7-0357]
ATGATCAGCTTGCCCGATCATCTCTTACAGGAAGTGGATGGGATCGCTCAATTGGAGAACTCTAACCGGAGTGAATTGAT
TAGGCAGGCCATGAAGCTGTATTTAAGCGAACGGAGGAAACGCATCATTCGTGAGTCCATGCAGCGGGGCTATATGGAAA
TGGCCAAGATCAATTTGACGATGGCATGCGAGGCCTTTCTCGCTGAGGAAGATGCAGACAGTACTCTTGGCCGCTTAGTA
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References