Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 761015..761580 Replicon chromosome
Accession NZ_CP009241
Organism Paenibacillus sp. FSL H7-0357

Toxin (Protein)


Gene name mazF Uniprot ID A0A089HYJ9
Locus tag H70357_RS03405 Protein ID WP_038585773.1
Coordinates 761239..761580 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A089J3Y9
Locus tag H70357_RS03400 Protein ID WP_038585771.1
Coordinates 761015..761245 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H70357_RS03375 757117..757806 - 690 WP_038585755.1 ABC transporter ATP-binding protein -
H70357_RS03380 757888..758877 - 990 WP_038585758.1 HAMP domain-containing histidine kinase -
H70357_RS03385 758864..759550 - 687 WP_038585761.1 response regulator transcription factor -
H70357_RS03395 759832..760821 + 990 WP_038585768.1 tRNA-dihydrouridine synthase -
H70357_RS03400 761015..761245 + 231 WP_038585771.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H70357_RS03405 761239..761580 + 342 WP_038585773.1 endoribonuclease MazF Toxin
H70357_RS03410 761623..761931 + 309 WP_038585776.1 hypothetical protein -
H70357_RS03415 762201..762769 + 569 Protein_651 hypothetical protein -
H70357_RS03420 762941..763270 + 330 WP_038585778.1 nucleotide pyrophosphohydrolase -
H70357_RS03425 763291..763845 + 555 WP_038585780.1 hypothetical protein -
H70357_RS03430 763884..765224 + 1341 WP_038585782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 750748..776760 26012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin

SpoVT-AbrB domain

(5-47)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12339.43 Da        Isoelectric Point: 7.8215

>T48584 WP_038585773.1 NZ_CP009241:761239-761580 [Paenibacillus sp. FSL H7-0357]
MVTGGYVPDRGDLVWLQFNPQAGHEQAGKRPALVVSPASYNGKVGLSLLCPVTSKQKGYPFEVVIPQDLPIEGVILADQV
KSLDWQSRQAVFICKVPQIILSDVVAKLDLLIR

Download         Length: 342 bp

>T48584 NZ_CP009241:761239-761580 [Paenibacillus sp. FSL H7-0357]
ATGGTAACGGGCGGGTATGTGCCGGATCGAGGCGACTTGGTATGGTTGCAGTTCAACCCGCAAGCGGGGCATGAACAGGC
AGGCAAACGTCCGGCCTTGGTCGTGTCTCCTGCTTCCTATAATGGTAAGGTCGGACTTTCCTTGCTCTGTCCGGTAACTT
CTAAACAAAAGGGCTACCCGTTTGAAGTAGTCATTCCGCAGGATCTGCCCATCGAAGGGGTTATCCTTGCCGATCAAGTA
AAGAGTCTTGATTGGCAATCCCGACAGGCAGTGTTCATCTGTAAAGTACCACAGATCATACTGTCAGATGTCGTTGCCAA
ACTCGACTTACTGATTCGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8466.57 Da        Isoelectric Point: 4.5800

>AT48584 WP_038585771.1 NZ_CP009241:761015-761245 [Paenibacillus sp. FSL H7-0357]
MFQVRKWGNSLGIRIPKSLALKVGIEEGSEVDLDVEDGHLIIKPKSATLDEILSQVTPENLHNEVSTGEQQGREVW

Download         Length: 231 bp

>AT48584 NZ_CP009241:761015-761245 [Paenibacillus sp. FSL H7-0357]
ATGTTTCAGGTTCGAAAATGGGGTAACAGCTTGGGCATTCGCATTCCGAAATCCCTTGCCCTAAAGGTCGGTATTGAGGA
AGGCTCCGAAGTCGATCTTGATGTGGAAGATGGACATCTTATCATCAAGCCGAAGTCGGCTACACTGGACGAAATCCTTT
CCCAGGTCACCCCGGAAAATCTCCATAATGAGGTCTCTACAGGCGAACAACAAGGACGGGAAGTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A089HYJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A089J3Y9

References