Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 761015..761580 Replicon chromosome
Accession NZ_CP009241
Organism Paenibacillus sp. FSL H7-0357

Toxin (Protein)


Gene name mazF Uniprot ID A0A089HYJ9
Locus tag H70357_RS03405 Protein ID WP_038585773.1
Coordinates 761239..761580 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A089J3Y9
Locus tag H70357_RS03400 Protein ID WP_038585771.1
Coordinates 761015..761245 (+) Length 77 a.a.

Genomic Context


H70357_RS03395H70357_RS03400H70357_RS03405H70357_RS03410H70357_RS03415H70357_RS03420H70357_RS03425H70357_RS03430H70357_RS03375H70357_RS03380H70357_RS03385
Location: 759832..760821 (990 bp)
Type: Others
Protein ID: WP_038585768.1
Location: 761015..761245 (231 bp)
Type: Antitoxin
Protein ID: WP_038585771.1
Location: 761239..761580 (342 bp)
Type: Toxin
Protein ID: WP_038585773.1
Location: 761623..761931 (309 bp)
Type: Others
Protein ID: WP_038585776.1
Location: 762201..762769 (569 bp)
Type: Others
Protein ID: Protein_651
Location: 762941..763270 (330 bp)
Type: Others
Protein ID: WP_038585778.1
Location: 763291..763845 (555 bp)
Type: Others
Protein ID: WP_038585780.1
Location: 763884..765224 (1341 bp)
Type: Others
Protein ID: WP_038585782.1
Location: 757117..757806 (690 bp)
Type: Others
Protein ID: WP_038585755.1
Location: 757888..758877 (990 bp)
Type: Others
Protein ID: WP_038585758.1
Location: 758864..759550 (687 bp)
Type: Others
Protein ID: WP_038585761.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H70357_RS03375757117..757806-690WP_038585755.1ABC transporter ATP-binding protein-
H70357_RS03380757888..758877-990WP_038585758.1HAMP domain-containing histidine kinase-
H70357_RS03385758864..759550-687WP_038585761.1response regulator transcription factor-
H70357_RS03395759832..760821+990WP_038585768.1tRNA-dihydrouridine synthase-
H70357_RS03400761015..761245+231WP_038585771.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
H70357_RS03405761239..761580+342WP_038585773.1endoribonuclease MazFToxin
H70357_RS03410761623..761931+309WP_038585776.1hypothetical protein-
H70357_RS03415762201..762769+569Protein_651hypothetical protein-
H70357_RS03420762941..763270+330WP_038585778.1nucleotide pyrophosphohydrolase-
H70357_RS03425763291..763845+555WP_038585780.1hypothetical protein-
H70357_RS03430763884..765224+1341WP_038585782.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--750748..77676026012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-112)

Antitoxin

(5-47)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12339.43 Da        Isoelectric Point: 7.8215

>T48584 WP_038585773.1 NZ_CP009241:761239-761580 [Paenibacillus sp. FSL H7-0357]
MVTGGYVPDRGDLVWLQFNPQAGHEQAGKRPALVVSPASYNGKVGLSLLCPVTSKQKGYPFEVVIPQDLPIEGVILADQV
KSLDWQSRQAVFICKVPQIILSDVVAKLDLLIR

Download         Length: 342 bp

>T48584 NZ_CP009241:761239-761580 [Paenibacillus sp. FSL H7-0357]
ATGGTAACGGGCGGGTATGTGCCGGATCGAGGCGACTTGGTATGGTTGCAGTTCAACCCGCAAGCGGGGCATGAACAGGC
AGGCAAACGTCCGGCCTTGGTCGTGTCTCCTGCTTCCTATAATGGTAAGGTCGGACTTTCCTTGCTCTGTCCGGTAACTT
CTAAACAAAAGGGCTACCCGTTTGAAGTAGTCATTCCGCAGGATCTGCCCATCGAAGGGGTTATCCTTGCCGATCAAGTA
AAGAGTCTTGATTGGCAATCCCGACAGGCAGTGTTCATCTGTAAAGTACCACAGATCATACTGTCAGATGTCGTTGCCAA
ACTCGACTTACTGATTCGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8466.57 Da        Isoelectric Point: 4.5800

>AT48584 WP_038585771.1 NZ_CP009241:761015-761245 [Paenibacillus sp. FSL H7-0357]
MFQVRKWGNSLGIRIPKSLALKVGIEEGSEVDLDVEDGHLIIKPKSATLDEILSQVTPENLHNEVSTGEQQGREVW

Download         Length: 231 bp

>AT48584 NZ_CP009241:761015-761245 [Paenibacillus sp. FSL H7-0357]
ATGTTTCAGGTTCGAAAATGGGGTAACAGCTTGGGCATTCGCATTCCGAAATCCCTTGCCCTAAAGGTCGGTATTGAGGA
AGGCTCCGAAGTCGATCTTGATGTGGAAGATGGACATCTTATCATCAAGCCGAAGTCGGCTACACTGGACGAAATCCTTT
CCCAGGTCACCCCGGAAAATCTCCATAATGAGGTCTCTACAGGCGAACAACAAGGACGGGAAGTATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A089HYJ9


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A089J3Y9

References