Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 761015..761580 | Replicon | chromosome |
Accession | NZ_CP009241 | ||
Organism | Paenibacillus sp. FSL H7-0357 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A089HYJ9 |
Locus tag | H70357_RS03405 | Protein ID | WP_038585773.1 |
Coordinates | 761239..761580 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A089J3Y9 |
Locus tag | H70357_RS03400 | Protein ID | WP_038585771.1 |
Coordinates | 761015..761245 (+) | Length | 77 a.a. |
Genomic Context
Location: 759832..760821 (990 bp)
Type: Others
Protein ID: WP_038585768.1
Type: Others
Protein ID: WP_038585768.1
Location: 761015..761245 (231 bp)
Type: Antitoxin
Protein ID: WP_038585771.1
Type: Antitoxin
Protein ID: WP_038585771.1
Location: 761239..761580 (342 bp)
Type: Toxin
Protein ID: WP_038585773.1
Type: Toxin
Protein ID: WP_038585773.1
Location: 761623..761931 (309 bp)
Type: Others
Protein ID: WP_038585776.1
Type: Others
Protein ID: WP_038585776.1
Location: 762201..762769 (569 bp)
Type: Others
Protein ID: Protein_651
Type: Others
Protein ID: Protein_651
Location: 762941..763270 (330 bp)
Type: Others
Protein ID: WP_038585778.1
Type: Others
Protein ID: WP_038585778.1
Location: 763291..763845 (555 bp)
Type: Others
Protein ID: WP_038585780.1
Type: Others
Protein ID: WP_038585780.1
Location: 763884..765224 (1341 bp)
Type: Others
Protein ID: WP_038585782.1
Type: Others
Protein ID: WP_038585782.1
Location: 757117..757806 (690 bp)
Type: Others
Protein ID: WP_038585755.1
Type: Others
Protein ID: WP_038585755.1
Location: 757888..758877 (990 bp)
Type: Others
Protein ID: WP_038585758.1
Type: Others
Protein ID: WP_038585758.1
Location: 758864..759550 (687 bp)
Type: Others
Protein ID: WP_038585761.1
Type: Others
Protein ID: WP_038585761.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H70357_RS03375 | 757117..757806 | - | 690 | WP_038585755.1 | ABC transporter ATP-binding protein | - |
H70357_RS03380 | 757888..758877 | - | 990 | WP_038585758.1 | HAMP domain-containing histidine kinase | - |
H70357_RS03385 | 758864..759550 | - | 687 | WP_038585761.1 | response regulator transcription factor | - |
H70357_RS03395 | 759832..760821 | + | 990 | WP_038585768.1 | tRNA-dihydrouridine synthase | - |
H70357_RS03400 | 761015..761245 | + | 231 | WP_038585771.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
H70357_RS03405 | 761239..761580 | + | 342 | WP_038585773.1 | endoribonuclease MazF | Toxin |
H70357_RS03410 | 761623..761931 | + | 309 | WP_038585776.1 | hypothetical protein | - |
H70357_RS03415 | 762201..762769 | + | 569 | Protein_651 | hypothetical protein | - |
H70357_RS03420 | 762941..763270 | + | 330 | WP_038585778.1 | nucleotide pyrophosphohydrolase | - |
H70357_RS03425 | 763291..763845 | + | 555 | WP_038585780.1 | hypothetical protein | - |
H70357_RS03430 | 763884..765224 | + | 1341 | WP_038585782.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 750748..776760 | 26012 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12339.43 Da Isoelectric Point: 7.8215
>T48584 WP_038585773.1 NZ_CP009241:761239-761580 [Paenibacillus sp. FSL H7-0357]
MVTGGYVPDRGDLVWLQFNPQAGHEQAGKRPALVVSPASYNGKVGLSLLCPVTSKQKGYPFEVVIPQDLPIEGVILADQV
KSLDWQSRQAVFICKVPQIILSDVVAKLDLLIR
MVTGGYVPDRGDLVWLQFNPQAGHEQAGKRPALVVSPASYNGKVGLSLLCPVTSKQKGYPFEVVIPQDLPIEGVILADQV
KSLDWQSRQAVFICKVPQIILSDVVAKLDLLIR
Download Length: 342 bp
>T48584 NZ_CP009241:761239-761580 [Paenibacillus sp. FSL H7-0357]
ATGGTAACGGGCGGGTATGTGCCGGATCGAGGCGACTTGGTATGGTTGCAGTTCAACCCGCAAGCGGGGCATGAACAGGC
AGGCAAACGTCCGGCCTTGGTCGTGTCTCCTGCTTCCTATAATGGTAAGGTCGGACTTTCCTTGCTCTGTCCGGTAACTT
CTAAACAAAAGGGCTACCCGTTTGAAGTAGTCATTCCGCAGGATCTGCCCATCGAAGGGGTTATCCTTGCCGATCAAGTA
AAGAGTCTTGATTGGCAATCCCGACAGGCAGTGTTCATCTGTAAAGTACCACAGATCATACTGTCAGATGTCGTTGCCAA
ACTCGACTTACTGATTCGCTGA
ATGGTAACGGGCGGGTATGTGCCGGATCGAGGCGACTTGGTATGGTTGCAGTTCAACCCGCAAGCGGGGCATGAACAGGC
AGGCAAACGTCCGGCCTTGGTCGTGTCTCCTGCTTCCTATAATGGTAAGGTCGGACTTTCCTTGCTCTGTCCGGTAACTT
CTAAACAAAAGGGCTACCCGTTTGAAGTAGTCATTCCGCAGGATCTGCCCATCGAAGGGGTTATCCTTGCCGATCAAGTA
AAGAGTCTTGATTGGCAATCCCGACAGGCAGTGTTCATCTGTAAAGTACCACAGATCATACTGTCAGATGTCGTTGCCAA
ACTCGACTTACTGATTCGCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8466.57 Da Isoelectric Point: 4.5800
>AT48584 WP_038585771.1 NZ_CP009241:761015-761245 [Paenibacillus sp. FSL H7-0357]
MFQVRKWGNSLGIRIPKSLALKVGIEEGSEVDLDVEDGHLIIKPKSATLDEILSQVTPENLHNEVSTGEQQGREVW
MFQVRKWGNSLGIRIPKSLALKVGIEEGSEVDLDVEDGHLIIKPKSATLDEILSQVTPENLHNEVSTGEQQGREVW
Download Length: 231 bp
>AT48584 NZ_CP009241:761015-761245 [Paenibacillus sp. FSL H7-0357]
ATGTTTCAGGTTCGAAAATGGGGTAACAGCTTGGGCATTCGCATTCCGAAATCCCTTGCCCTAAAGGTCGGTATTGAGGA
AGGCTCCGAAGTCGATCTTGATGTGGAAGATGGACATCTTATCATCAAGCCGAAGTCGGCTACACTGGACGAAATCCTTT
CCCAGGTCACCCCGGAAAATCTCCATAATGAGGTCTCTACAGGCGAACAACAAGGACGGGAAGTATGGTAA
ATGTTTCAGGTTCGAAAATGGGGTAACAGCTTGGGCATTCGCATTCCGAAATCCCTTGCCCTAAAGGTCGGTATTGAGGA
AGGCTCCGAAGTCGATCTTGATGTGGAAGATGGACATCTTATCATCAAGCCGAAGTCGGCTACACTGGACGAAATCCTTT
CCCAGGTCACCCCGGAAAATCTCCATAATGAGGTCTCTACAGGCGAACAACAAGGACGGGAAGTATGGTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A089HYJ9 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A089J3Y9 |