Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2265221..2265998 Replicon chromosome
Accession NZ_CP009237
Organism Glaesserella parasuis strain KL0318

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag JT17_RS11170 Protein ID WP_005710654.1
Coordinates 2265221..2265721 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag JT17_RS11175 Protein ID WP_005710653.1
Coordinates 2265711..2265998 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT17_RS11885 2260346..2260501 - 156 WP_005710668.1 YoaH family protein -
JT17_RS11140 2260519..2261247 - 729 WP_038513732.1 tRNA pseudouridine(65) synthase TruC -
JT17_RS11145 2261244..2261558 - 315 WP_005710664.1 YqcC family protein -
JT17_RS11150 2261600..2262514 - 915 WP_044009507.1 N-acetylmuramic acid 6-phosphate etherase -
JT17_RS11155 2262526..2263641 - 1116 WP_044009508.1 anhydro-N-acetylmuramic acid kinase -
JT17_RS11160 2263796..2264131 - 336 WP_005710658.1 outer membrane protein assembly factor BamE -
JT17_RS11165 2264192..2265193 - 1002 WP_005710656.1 nucleoid-associated protein YejK -
JT17_RS11170 2265221..2265721 - 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
JT17_RS11175 2265711..2265998 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
JT17_RS11180 2266144..2266533 + 390 WP_012621873.1 RidA family protein -
JT17_RS11185 2266537..2267274 + 738 WP_044009509.1 peptidoglycan editing factor PgeF -
JT17_RS11190 2267449..2269026 + 1578 WP_005710646.1 FAD-binding protein -
JT17_RS11195 2269131..2269631 + 501 WP_016527798.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T48583 WP_005710654.1 NZ_CP009237:c2265721-2265221 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T48583 NZ_CP009237:c2265721-2265221 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCTGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT48583 WP_005710653.1 NZ_CP009237:c2265998-2265711 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT48583 NZ_CP009237:c2265998-2265711 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References