Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1547991..1549540 Replicon chromosome
Accession NZ_CP009237
Organism Glaesserella parasuis strain KL0318

Toxin (Protein)


Gene name hipA Uniprot ID A0A1S9ZYJ4
Locus tag JT17_RS07490 Protein ID WP_044009327.1
Coordinates 1547991..1549307 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag JT17_RS07495 Protein ID WP_010786623.1
Coordinates 1549301..1549540 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT17_RS07460 1543545..1544138 - 594 WP_005714214.1 sugar O-acetyltransferase -
JT17_RS07465 1544228..1544824 - 597 Protein_1468 disulfide bond formation protein DsbA -
JT17_RS07470 1544788..1545111 + 324 Protein_1469 LysR family transcriptional regulator -
JT17_RS07475 1545215..1546201 - 987 WP_005714908.1 IS110 family transposase -
JT17_RS12305 1546607..1546843 + 237 WP_198354994.1 hypothetical protein -
JT17_RS07485 1546851..1547987 + 1137 WP_198355003.1 PLP-dependent aminotransferase family protein -
JT17_RS07490 1547991..1549307 - 1317 WP_044009327.1 type II toxin-antitoxin system HipA family toxin Toxin
JT17_RS07495 1549301..1549540 - 240 WP_010786623.1 helix-turn-helix domain-containing protein Antitoxin
JT17_RS07500 1549688..1550515 - 828 WP_005713289.1 alpha/beta hydrolase -
JT17_RS07505 1550646..1552091 + 1446 WP_044009328.1 metalloprotease TldD -
JT17_RS07510 1552345..1552755 + 411 WP_044009329.1 preprotein translocase subunit SecE -
JT17_RS07515 1552757..1553335 + 579 WP_020457616.1 transcription termination/antitermination protein NusG -
JT17_RS07520 1553461..1553715 - 255 WP_005713300.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 50015.25 Da        Isoelectric Point: 7.3465

>T48582 WP_044009327.1 NZ_CP009237:c1549307-1547991 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Download         Length: 1317 bp

>T48582 NZ_CP009237:c1549307-1547991 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCTTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCGAATCATCGAATAATTCAAGCCACAGAATTAGACGAAAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCACTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGTACACAAAAAGGGAAAAAATGGCATTGGAATAAAATTTACGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT48582 WP_010786623.1 NZ_CP009237:c1549540-1549301 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp

>AT48582 NZ_CP009237:c1549540-1549301 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S9ZYJ4

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References